Wysocki H, Wierusz-Wysocka B, Prazmowska-Owczarek B, Hansz J
Acta Haematol Pol. 1976;7(2):117-22.
The ability of neutrophil granulocytes to mobilization in sterile inflammatory focus was studied in patients with Hodgkin's disease during treatment. Plastic chambers filled with patient's serum were used for this purpose. The migration ability of granulocytes in the group of patients was reduced already before beginning of treatment. It decreased even more 3 days after beginning of cytostatic treatment but on the 7th day the number of cells passing into the inflammatory exudate increased to values observed in healthy subjects. The observed changes were not correlated with fluctuations in the granulocyte count in the peripheral blood observed on the same days. It is suggested that the evaluation of migration ability of granulocytes to the inflammatory focus may provide better information about the defensive mechanisms of the organism than determination of the count of these cells in the peripheral blood.
在治疗期间，对霍奇金病患者中性粒细胞在无菌性炎症病灶中动员的能力进行了研究。为此使用了装有患者血清的塑料小室。在治疗开始前，患者组中粒细胞的迁移能力就已经降低。在开始细胞抑制治疗3天后，其迁移能力进一步下降，但在第7天，进入炎症渗出液的细胞数量增加到了在健康受试者中观察到的值。观察到的这些变化与同一天外周血中粒细胞计数的波动无关。有人提出，评估粒细胞向炎症病灶的迁移能力可能比测定外周血中这些细胞的数量能提供有关机体防御机制的更好信息。
