A. N. Bakulev National Medical Research Center of Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Bull Exp Biol Med. 2023 May;175(1):162-171. doi: 10.1007/s10517-023-05829-8. Epub 2023 Jun 19.
In patients with an ascending aorta aneurysm, restructuring of all its layers and, first of all, the intima and media was revealed. The thickness of the intima was 79.3±63.1 μm in patients with aortic diameter <55 mm (group Ao<55) and 162.7±177.4 μm (p<0.05) in patients with aortic diameter ⩾55 mm (Ao⩾55 group), the thickness of the aortic media was 1184.0±198.2 and 1144.3±288.4 μm, respectively. In patients of the Ao<55 group, aortic dilatation was accompanied by compensatory thickening of the inner and middle layers of the aorta. In the Ao⩾55 group, thinning of the aortic media, fragmentation of elastic fibers, and its cystic degeneration were revealed. c-kit Stem cells were detected in the subendothelium of the thickened intima of the dilated ascending aorta. The appearance of c-kit cells correlated with intimal remodeling and its colonization with CD34 and CD44 myofibroblast-like cells.
在升主动脉瘤患者中，所有层，尤其是内膜和中膜，均发生重构。主动脉直径<55 mm（Ao<55 组）患者的内膜厚度为 79.3±63.1 μm，主动脉直径 ⩾55 mm（Ao⩾55 组）患者的内膜厚度为 162.7±177.4 μm（p<0.05），主动脉中膜的厚度分别为 1184.0±198.2 和 1144.3±288.4 μm。在 Ao<55 组患者中，主动脉扩张伴有内、中膜的代偿性增厚。在 Ao⩾55 组中，发现中膜变薄、弹性纤维碎裂和囊性变性。在扩张的升主动脉增厚内膜的内皮下检测到 c-kit 干细胞。c-kit 细胞的出现与内膜重构及其与 CD34 和 CD44 肌纤维母细胞样细胞的定植相关。
