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Roux-en-Y 胃旁路术对 2 型糖尿病的体重相关与非体重相关作用。

Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes.

机构信息

Center for Human Nutrition, Washington University, St. Louis, Missouri, USA.

Sansum Diabetes Research Institute, Santa Barbara, CA, USA.

出版信息

Nat Metab. 2023 Jun;5(6):912-914. doi: 10.1038/s42255-023-00823-w.

DOI:10.1038/s42255-023-00823-w
PMID:37337127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10440834/
Abstract

Many people with obesity and type 2 diabetes achieve remission of their diabetes after Roux-en-Y Gastric Bypass Surgery but the mechanisms remain disputed. We provide our perspective on competing data sets that either point towards this effect being entirely due to the loss of weight, or due to weight loss-independent effects.

摘要

许多肥胖和 2 型糖尿病患者在接受 Roux-en-Y 胃旁路手术后糖尿病得到缓解，但机制仍存在争议。我们提供了对相互竞争的数据的看法，这些数据要么表明这种效果完全是由于体重减轻，要么是由于与体重减轻无关的影响。

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Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes.Roux-en-Y 胃旁路术对 2 型糖尿病的体重相关与非体重相关作用。
Nat Metab. 2023 Jun;5(6):912-914. doi: 10.1038/s42255-023-00823-w.
2
Roux-en-Y gastric bypass decreases serum inflammatory markers and cardiovascular risk factors in obese diabetics.胃旁路手术可降低肥胖糖尿病患者的血清炎症标志物和心血管危险因素。
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[Comparative effects of Roux-en-Y gastric bypass procedures preserving different gastric volume on blood glucose in Goto-Kakizaki rats].[保留不同胃容积的Roux-en-Y胃旁路手术对Goto-Kakizaki大鼠血糖的比较影响]
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[Comparison of 1-year outcomes between Roux-en-Y gastric bypass and sleeve gastrectomy with Roux-en-Y duodenojejunal bypass in the patients of obesity with type 2 diabetes mellitus].[肥胖合并2型糖尿病患者中Roux-en-Y胃旁路术与袖状胃切除术加Roux-en-Y十二指肠空肠旁路术1年结局的比较]
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本文引用的文献

1
Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion.VSG 后肠道 HIF2α 信号增加，肠道 HIF2α 的激活可减轻体重、改善葡萄糖代谢并增加 GLP-1 分泌。
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Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes.饮食与胃旁路手术对糖尿病代谢功能的影响。
N Engl J Med. 2020 Aug 20;383(8):721-732. doi: 10.1056/NEJMoa2003697.
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Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression.Roux-en-Y 胃旁路手术通过 FXR 介导的 TRPA1 表达增强 2 型糖尿病的胰岛素分泌。
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Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass.胆胰旁路术比 Roux-en-Y 胃旁路术更能改善代谢。
Cell Metab. 2019 Nov 5;30(5):855-864.e3. doi: 10.1016/j.cmet.2019.09.002. Epub 2019 Oct 3.
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Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.胃旁路手术后，β细胞对葡萄糖的敏感性降低。
Diabetes Obes Metab. 2018 Apr;20(4):872-878. doi: 10.1111/dom.13165. Epub 2017 Dec 18.
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Glucose Metabolism After Gastric Banding and Gastric Bypass in Individuals With Type 2 Diabetes: Weight Loss Effect.2型糖尿病患者胃束带术和胃旁路术后的葡萄糖代谢：体重减轻效果
Diabetes Care. 2017 Jan;40(1):7-15. doi: 10.2337/dc16-1376. Epub 2016 Nov 8.
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Calorie restriction and not glucagon-like peptide-1 explains the acute improvement in glucose control after gastric bypass in Type 2 diabetes.热量限制而非胰高血糖素样肽-1解释了2型糖尿病患者胃旁路术后血糖控制的急性改善。
Diabet Med. 2016 Dec;33(12):1723-1731. doi: 10.1111/dme.13257. Epub 2016 Oct 8.
10
The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes.肠道适应性在多种减肥手术对肥胖症和糖尿病的显著疗效中的作用。
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