越南两种植物（和）精油的化学成分、抗炎和细胞毒性活性。
Chemical composition, anti-inflammatory and cytotoxic activity of essential oils from two species ( and ) from Vietnam.
机构信息
Faculty of Chemistry and Environment, Dalat University, Dalat, Vietnam.
Faculty of Biology, Dalat University, Dalat, Vietnam.
出版信息
Nat Prod Res. 2024 Jun;38(11):1834-1843. doi: 10.1080/14786419.2023.2225125. Epub 2023 Jun 19.
New essential oils (EOs) extracted from different parts of two species ( and ) from Vietnam were investigated for their chemical composition, anti-inflammatory and cytotoxic activity. Sixty-nine total compounds were identified in the EOs by GC/MS. The major constituent of the leaf, fruit, and root EOs from was β-caryophyllene (71.5%, 63.0%, and 31.5% respectively). The main compounds in EOs were β-elemene (34.3% in leaf oil) and caryophyllene oxide (21.2% in root oil, 19.4% in stem oil). The EO from fruits significantly inhibited nitric oxide production on LPS-induced RAW264.7 cells (IC = 37.95 ± 2.76 µg/mL). The EOs from roots and leaves and fruits exhibited cytotoxic activity against MCF-7, SK-LU-1, and HepG2 (IC from 49.74 ± 3.36 to 97.82 ± 8.61 µg/mL). This is the first report on EOs and significantly complements the composition and bioactivity of EOs.
从越南的两种植物（和）的不同部位提取的新精油（EOs），其化学成分、抗炎和细胞毒性活性进行了研究。通过 GC/MS 鉴定了精油中的 69 种化合物。叶片、果实和根精油中 的主要成分分别为β-石竹烯（71.5%、63.0%和 31.5%）。精油中的主要化合物为β-榄香烯（叶油中 34.3%）和石竹烯氧化物（根油中 21.2%，茎油中 19.4%）。 果实精油对 LPS 诱导的 RAW264.7 细胞的一氧化氮生成具有显著抑制作用（IC = 37.95 ± 2.76 μg/mL）。根和叶及果实精油对 MCF-7、SK-LU-1 和 HepG2 具有细胞毒性活性（IC 从 49.74 ± 3.36 到 97.82 ± 8.61 μg/mL）。这是关于精油的首次报道，显著补充了精油的组成和生物活性。
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