V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Bull Exp Biol Med. 2023 May;175(1):59-62. doi: 10.1007/s10517-023-05811-4. Epub 2023 Jun 20.
We studied the effects of oral administration of Afobazole in a dose of 10 mg/kg for 5 days on depressive-like behavior of male C57BL/6 mice in the tail suspension test in comparison with amitriptyline (10 mg/kg) or fluoxetine (20 mg/kg) treatment. Afobazole produced an antidepressant effect similar to amitriptyline, but inferior to fluoxetine. The σ1 receptor antagonist BD-1047 in a dose of 5 mg/kg blocked the antidepressant effect of Afobazole, which indicates the involvement of σ1 receptors in the antidepressant effect of the drug.
我们研究了阿法佐扎（剂量为 10mg/kg，连续给药 5 天）对雄性 C57BL/6 小鼠悬尾试验中抑郁样行为的影响，并与阿米替林（10mg/kg）或氟西汀（20mg/kg）进行了比较。阿法佐扎产生了一种类似于阿米替林的抗抑郁作用，但不如氟西汀。σ1 受体拮抗剂 BD-1047（剂量为 5mg/kg）阻断了阿法佐扎的抗抑郁作用，这表明 σ1 受体参与了该药物的抗抑郁作用。
