Department of Biochemistry, University of Geneva, Geneva, Switzerland.
J Cell Biol. 2023 Jul 3;222(7). doi: 10.1083/jcb.202306059. Epub 2023 Jun 20.
Conserved protein complexes called ESCRTs (endosomal sorting complexes in retrograde transport) exert diverse membrane remodeling and repair functions in cells. Hakala and Roux discuss a novel type of ESCRT-III structure found by Stempels et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202205130) in migrating macrophages and dendritic cells, suggesting a novel, cell type-specific function for this complex.
被称为 ESCRTs（逆向运输内体分选复合物）的保守蛋白复合物在细胞中发挥多种膜重塑和修复功能。Hakala 和 Roux 讨论了 Stempels 等人（2023. J. Cell Biol.https://doi.org/10.1083/jcb.202205130）在迁移巨噬细胞和树突状细胞中发现的一种新型 ESCRT-III 结构，这表明该复合物具有新的、细胞类型特异性的功能。
