van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
Angew Chem Int Ed Engl. 2023 Oct 9;62(41):e202306645. doi: 10.1002/anie.202306645. Epub 2023 Jul 7.
The importance of transition metal catalysis is exemplified by its wide range of applications, for example in the synthesis of chemicals, natural products, and pharmaceuticals. However, one relatively new application is for carrying out new-to-nature reactions inside living cells. The complex environment of a living cell is not welcoming to transition metal catalysts, as a diverse range of biological components have the potential to inhibit or deactivate the catalyst. Here we review the current progress in the field of transition metal catalysis, and evaluation of catalysis efficiency in living cells and under biological (relevant) conditions. Catalyst poisoning is a ubiquitous problem in this field, and we propose that future research into the development of physical and kinetic protection strategies may provide a route to improve the reactivity of catalysts in cells.
过渡金属催化的重要性体现在其广泛的应用上，例如在化学品、天然产物和药物的合成中。然而，一个相对较新的应用是在活细胞内进行新的天然反应。活细胞的复杂环境对过渡金属催化剂并不友好，因为各种生物成分有可能抑制或使催化剂失活。在这里，我们综述了过渡金属催化领域的最新进展，并评估了在活细胞中和在生物学（相关）条件下的催化效率。催化剂中毒是该领域普遍存在的问题，我们提出，未来对物理和动力学保护策略的研究可能为提高催化剂在细胞中的反应性提供一条途径。
