Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.
Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.
Curr Opin Chem Biol. 2021 Apr;61:32-42. doi: 10.1016/j.cbpa.2020.10.001. Epub 2020 Nov 2.
The incorporation of abiotic transition metal catalysis into the chemical biology space has significantly expanded the tool kit of bioorthogonal chemistries accessible for cell culture and in vivo applications. A rich variety of homogeneous and heterogeneous catalysts has shown functional compatibility with physiological conditions and biostability in complex environs, enabling their exploitation as extracellular or intracellular factories of bioactive agents. Current trends in the field are focusing on investigating new metals and sophisticated catalytic devices and toward more applied activities, such as the integration of subcellular, cell- and site-targeting capabilities or the exploration of novel biomedical applications. We present herein an overview of the latest advances in the field, highlighting the increasing role of transition metals for the controlled release of therapeutics.
将非生物过渡金属催化纳入化学生物学领域，极大地扩展了可用于细胞培养和体内应用的生物正交化学工具箱。丰富多样的均相和多相催化剂已显示出与生理条件的功能兼容性和在复杂环境中的生物稳定性，使其能够作为细胞外或细胞内生物活性物质的工厂进行利用。该领域目前的趋势集中在研究新的金属和复杂的催化装置，并朝着更具应用活性的方向发展，例如亚细胞、细胞和部位靶向能力的整合，或探索新的生物医学应用。本文概述了该领域的最新进展，强调了过渡金属在控制释放治疗剂方面的作用日益增加。
