Market Access, Public Affairs & Patient Experience, Japan Pharma Business Unit, Takeda Pharmaceutical Company Limited, Tokyo, Japan.
Department of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Expert Rev Pharmacoecon Outcomes Res. 2023 Jul-Dec;23(7):749-759. doi: 10.1080/14737167.2023.2223984. Epub 2023 Jun 20.
Value-based pricing (VBP) can be a promising tool for optimizing drug prices. However, there is no consensus on the specific value elements and pricing method that should be used for VBP.
We performed a systematic review and narrative synthesis to investigate the value elements and pricing method for VBP. The main inclusion criterion was that value elements, VBP method, and estimated prices for actual drugs were reported. We performed a search in MEDLINE and ICHUSHI Web. Eight articles met the selection criteria. Four studies adopted the cost-effectiveness analysis (CEA) approach and the others used different approaches. The CEA approach included the value elements of productivity, value of hope, real option value, disease severity, insurance value in addition to costs and quality-adjusted life years. The other approaches used efficacy, toxicity, novelty, rarity, research and development costs, prognosis, population health burden, unmet needs, and effectiveness. Each study used individual methods to quantify these broader value elements.
Both conventional and broader value elements are used for VBP. To allow VBP to be widely applied to various diseases, a simple, versatile method is preferable. Further research is needed to establish VBP method which enables to incorporate broader values.
基于价值的定价（VBP）可以成为优化药品价格的一种有前途的工具。然而，对于应该用于 VBP 的具体价值要素和定价方法，尚未达成共识。
我们进行了系统评价和叙述性综合，以调查 VBP 的价值要素和定价方法。主要纳入标准是报告了价值要素、VBP 方法和实际药物的估计价格。我们在 MEDLINE 和 ICHUSHI Web 上进行了搜索。有 8 篇文章符合选择标准。四项研究采用了成本效益分析（CEA）方法，其他研究则采用了不同的方法。CEA 方法包括生产力、希望价值、实物期权价值、疾病严重程度、保险价值，以及成本和质量调整生命年。其他方法使用了疗效、毒性、新颖性、稀有性、研发成本、预后、人口健康负担、未满足的需求和有效性。每项研究都使用了单独的方法来量化这些更广泛的价值要素。
传统和更广泛的价值要素都用于 VBP。为了使 VBP 能够广泛应用于各种疾病，最好使用简单、通用的方法。需要进一步研究来建立能够纳入更广泛价值的 VBP 方法。
