Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, USA; email:
Annu Rev Cell Dev Biol. 2023 Oct 16;39:391-408. doi: 10.1146/annurev-cellbio-120420-103941. Epub 2023 Jun 20.
Cell-cell communication is critical for the development and function of multicellular organisms. A crucial means by which cells communicate with one another is physical interactions between receptors on one cell and their ligands on a neighboring cell. ligand:receptor interactions activate the receptor, ultimately leading to changes in the fate of the receptor-expressing cells. Such signaling is known to be critical for the functions of cells in the nervous and immune systems, among others. Historically, interactions are the primary conceptual framework for understanding cell-cell communication. However, cells often coexpress many receptors and ligands, and a subset of these has been reported to interact in and profoundly impact cell functions. interactions likely constitute a fundamental, understudied regulatory mechanism in cell biology. Here, I discuss how interactions between membrane receptors and ligands regulate immune cell functions, and I also highlight outstanding questions in the field.
细胞间通讯对于多细胞生物的发育和功能至关重要。细胞间相互通讯的一个关键手段是相邻细胞上受体与其配体之间的物理相互作用。配体-受体相互作用激活受体，最终导致表达受体的细胞命运发生变化。这种信号传递被认为对神经系统和免疫系统等细胞的功能至关重要。历史上，细胞间相互作用是理解细胞间通讯的主要概念框架。然而，细胞通常共表达许多受体和配体，并且据报道其中一部分以配体-受体相互作用的形式存在，并深刻影响细胞功能。配体-受体相互作用可能构成细胞生物学中一个基本但研究不足的调节机制。在这里，我讨论了膜受体和配体之间的配体-受体相互作用如何调节免疫细胞功能，并且还强调了该领域的一些悬而未决的问题。
