细胞表面受体的顺反交互作用：生物学作用和结构基础。
Cis-trans interactions of cell surface receptors: biological roles and structural basis.
机构信息
Ludwig Center for Cancer Research of the University of Lausanne, 1066 Epalinges, Switzerland.
出版信息
Cell Mol Life Sci. 2011 Nov;68(21):3469-78. doi: 10.1007/s00018-011-0798-z. Epub 2011 Aug 24.
Abstract
Cell surface receptors bind ligands expressed on other cells (in trans) in order to communicate with neighboring cells. However, an increasing number of cell surface receptors are found to also interact with ligands expressed on the same cell (in cis). These observations raise questions regarding the biological role of such cis interactions. Specifically, it is important to know whether cis and trans binding have distinct functional effects and, if so, how a single cell discriminates between interactions in cis versus trans. Further, what are the structural features that allow certain cell surface receptors to engage ligand both on the same as well as on an apposed cell membrane? Here, we summarize known examples of receptors that display cis-trans binding and discuss the emerging diversity of biological roles played by these unconventional two-way interactions, along with their structural basis.
摘要
细胞表面受体与其他细胞上表达的配体结合（反式），以与相邻细胞进行通讯。然而，越来越多的细胞表面受体也被发现与同一细胞上表达的配体相互作用（顺式）。这些观察结果引发了关于这种顺式相互作用的生物学作用的问题。具体来说，重要的是要知道顺式和反式结合是否具有不同的功能影响，如果是这样，那么单个细胞如何区分顺式和反式相互作用。此外，哪些结构特征允许某些细胞表面受体与同一以及相邻细胞膜上的配体结合？在这里，我们总结了显示顺式-反式结合的受体的已知例子，并讨论了这些非传统双向相互作用所扮演的新兴生物学作用的多样性，以及它们的结构基础。
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