Department of Pathology and Dental Clinics, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella - Ininga, Teresina, Piauí 64049-550, Brazil.
Department of Periodontology, Federal University of Pelotas, Rua Gonçalves Chaves, 457 - Centro, Pelotas, Rio Grande do Sul 96015-560, Brazil.
J Dent. 2023 Aug;135:104586. doi: 10.1016/j.jdent.2023.104586. Epub 2023 Jun 18.
This review aimed to assess the agreement of dental caries experience between monozygotic (MZ) and dizygotic (DZ) twins.
This systematic review was performed by reviewers in the databases Embase, MEDLINE-PubMed, Scopus, Web of Science and manual searches and gray literature Google Scholar® and Opengray. Observational studies that evaluated dental caries in twins were included. The risk of bias was analyzed using the Joanna Briggs checklist. Meta-analyses were performed to assess the pooled Odds Ratio to estimate the agreement values of dental caries experience and DMF index between pairs of twins (p < 0.05). To assess the certainty of evidence, the GRADE scale was used.
2533 studies were identified, of which 19 were included in the qualitative analysis, six in the quantitative synthesis, with two meta-analyses being carried out. Association between genetics and the development of the disease was observed in most studies. In the risk of bias analysis, 47.4% had moderate risk. Higher agreement of dental caries experience was observed in MZ twins than DZ in both dentitions (OR: 5.94; 95% CI: 2.00-17.57). However, there was no difference between the MZ and DZ twin groups in the analysis comparing DMF index agreement (OR: 2.86; 95%CI: 0.25-32.79). The certainty of evidence was considered low and very low for all studies included in meta-analyses.
With very low certainty of the evidence, the genetic factor seems to influence the agreement of the caries experience.
Understanding the genetic influence on the disease has the potential to contribute to the development of studies that may use biotechnologies for prevention and treatment as well as guide future research involving gene therapies aiming to prevent the occurrence of dental caries.
本综述旨在评估同卵（MZ）和异卵（DZ）双胞胎的龋齿经历的一致性。
本系统评价由 Embase、MEDLINE-PubMed、Scopus、Web of Science 以及手动搜索和灰色文献 Google Scholar® 和 Opengray 中的评审员进行。纳入评估双胞胎龋齿的观察性研究。使用 Joanna Briggs 清单分析偏倚风险。进行荟萃分析以评估汇总 Odds Ratio，以估计双胞胎之间龋齿经历和 DMF 指数的一致性值（p<0.05）。使用 GRADE 量表评估证据的确定性。
确定了 2533 项研究，其中 19 项纳入定性分析，6 项纳入定量综合分析，进行了两项荟萃分析。大多数研究观察到遗传与疾病发展之间的关联。在偏倚风险分析中，47.4%的研究具有中度风险。在两种牙列中，MZ 双胞胎的龋齿经历一致性均高于 DZ 双胞胎（OR：5.94；95%CI：2.00-17.57）。然而，在比较 DMF 指数一致性的分析中，MZ 和 DZ 双胞胎组之间没有差异（OR：2.86；95%CI：0.25-32.79）。所有纳入荟萃分析的研究的证据确定性均为低和极低。
遗传因素似乎影响龋齿经历的一致性，但证据确定性非常低。
了解疾病的遗传影响有可能促进研究的发展，这些研究可能使用生物技术进行预防和治疗，并指导未来涉及基因治疗以预防龋齿发生的研究。
