细胞内递送一种能够抑制 c-Myc 的抗体样分子。
Intracellular Delivery of an Antibody-Like Molecule Capable of Inhibiting c-Myc.
机构信息
Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Moscow State University, Moscow, Russia.
出版信息
Dokl Biochem Biophys. 2023 Apr;509(1):70-72. doi: 10.1134/S1607672923700114. Epub 2023 Jun 20.
PMID:37340296
Abstract
A modular nanotransporter (MNT) carrying the sequence of an antibody-like molecule, anti-c-Myc nanobody, was synthesized and characterized. It was demonstrated that the created MNT is able to interact with the target protein, c-Myc oncogene, with a dissociation constant of 46 ± 14 nM, internalize into target cells, change Myc-dependent expression, and exert an antiproliferative effect.
摘要
一种携带抗体样分子（抗 c-Myc 纳米抗体）序列的模块化纳米转运体（MNT）被合成并进行了表征。结果表明，所构建的 MNT 能够与靶蛋白 c-Myc 癌基因相互作用，其解离常数为 46±14 nM，能够内化进入靶细胞，改变 Myc 依赖性表达，并发挥抗增殖作用。
Zotero 插件