Li Dandan, Zhao Yuxin, Zhang Lifang, You Qiqi, Jiang Qingqing, Yin Xiaoxv, Cao Shiyi
Department of Medical Records Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Shenzhen Fuyong People's Hospital, Shenzhen, Guangdong, China.
Diabetol Metab Syndr. 2023 Jun 21;15(1):133. doi: 10.1186/s13098-023-01111-z.
Despite that several original researchers have investigated the association between neck circumference (NC) and the risk of diabetes mellitus (DM), their results remain controversial. This review aimed to quantitatively determine the risk of DM in relation to the NC.
We conducted a literature search of PubMed, Embase, and the Web of Science from these databases' inception through September 2022 to identify observational studies that examined the association between NC and the risk of DM. A meta-analysis of the random-effects model was applied to combine the results of the enrolled studies.
Sixteen observational studies involving 4,764 patients with DM and 26,159 participants were assessed. The pooled results revealed that NC was significantly associated with the risk of type 2 DM (T2DM) (OR = 2.17; 95% CI: 1.30-3.62) and gestational DM (GDM) (OR = 1.31; 95% CI: 1.17-1.48). Subgroup analysis revealed that after controlling for BMI, the relationship between the NC and T2DM remained statistically significant (OR = 1.94; 95% CI: 1.35-2.79). Moreover, the pooled OR of T2DM was found to be 1.16 (95% CI: 1.07-1.27) for an increment per each centimeter in the NC.
Integrated epidemiological evidence supports the hypothesis that a greater NC is associated with an increased risk of T2DM and GDM.
尽管已有多项原创研究探讨了颈围（NC）与糖尿病（DM）风险之间的关联，但其结果仍存在争议。本综述旨在定量确定与颈围相关的糖尿病风险。
我们对PubMed、Embase和Web of Science数据库从建库至2022年9月进行了文献检索，以识别研究颈围与糖尿病风险之间关联的观察性研究。采用随机效应模型进行荟萃分析，以合并纳入研究的结果。
评估了16项观察性研究，涉及4764例糖尿病患者和26159名参与者。汇总结果显示，颈围与2型糖尿病（T2DM）风险（OR = 2.17；95% CI：1.30 - 3.62）和妊娠期糖尿病（GDM）风险（OR = 1.31；95% CI：1.17 - 1.48）显著相关。亚组分析显示，在控制体重指数（BMI）后，颈围与T2DM之间的关系仍具有统计学意义（OR = 1.94；95% CI：1.35 - 2.79）。此外，发现颈围每增加1厘米，T2DM的合并OR为1.16（95% CI：1.07 - 1.27）。
综合流行病学证据支持以下假设，即颈围越大，T2DM和GDM风险越高。
