维生素 D 受体基因 rs739837 多态性与 2 型糖尿病和妊娠期糖尿病易感性的关联：系统评价和荟萃分析。

Association of vitamin D receptor gene rs739837 polymorphism with type 2 diabetes and gestational diabetes mellitus susceptibility: a systematic review and meta-analysis.

机构信息

Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, 528300, Guangdong, People's Republic of China.

Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, 528300, Guangdong, People's Republic of China.

出版信息

Eur J Med Res. 2022 May 7;27(1):65. doi: 10.1186/s40001-022-00688-x.

BACKGROUND

Increasing evidence shows that genetic variants of genes in the diabetes mellitus (DM) metabolic pathway, such as the vitamin D receptor (VDR) gene rs739837 polymorphism, increase the risk of DM susceptibility. However, the findings have been inconsistent. The present study was performed to evaluate the association of VDR gene rs739837 and type 2 diabetes (T2DM) or gestational diabetes mellitus (GDM) risk.

METHODS

A comprehensive meta-analysis and a subgroup analysis were conducted to assess the association between VDR rs739837 and T2DM or GDM among five genetic models (dominant, recessive, homozygote heterozygote, and allele models) using a fixed or random model.

RESULTS

The meta-analysis included 9 studies. In the overall analysis, the results showed that VDR rs739837 was associated with an increased risk of T2DM or GDM in the allele model (T vs. G: OR = 1.088; 95% CI: 1.018-1.163; P = 0.012) and dominant model (TT + GT vs. GG: OR = 1.095; 95% CI: 1.001-1.197; P = 0.047). In the subgroup analysis, VDR rs739837 was also associated with an increased risk of T2DM in the allele model (T vs. G: OR = 1.159; 95% CI: 1.055-1.273; P = 0.002) and dominant model (TT + GT vs. GG: OR = 1.198; 95% CI: 1.048-1.370; P = 0.008). However, VDR rs739837 was not associated with GDM.

CONCLUSIONS

Significant associations were found between the VDR rs739837 polymorphism and T2DM susceptibility, but not with GDM.

背景

越来越多的证据表明，糖尿病（DM）代谢途径中基因的遗传变异，如维生素 D 受体（VDR）基因 rs739837 多态性，增加了 DM 易感性的风险。然而，研究结果并不一致。本研究旨在评估 VDR 基因 rs739837 与 2 型糖尿病（T2DM）或妊娠期糖尿病（GDM）风险的关系。

方法

采用固定或随机模型，在五种遗传模型（显性、隐性、纯合子杂合子、等位基因模型）下，进行综合荟萃分析和亚组分析，以评估 VDR rs739837 与 T2DM 或 GDM 之间的关联。

结果

荟萃分析共纳入 9 项研究。在总体分析中，结果显示 VDR rs739837 与 T2DM 或 GDM 的等位基因模型（T 对 G：OR=1.088；95%CI：1.018-1.163；P=0.012）和显性模型（TT+GT 对 GG：OR=1.095；95%CI：1.001-1.197；P=0.047）有关。在亚组分析中，VDR rs739837 与 T2DM 的等位基因模型（T 对 G：OR=1.159；95%CI：1.055-1.273；P=0.002）和显性模型（TT+GT 对 GG：OR=1.198；95%CI：1.048-1.370；P=0.008）也存在相关性。然而，VDR rs739837 与 GDM 无关。