Chen Shu-Ya, Ni An-Yu, Qian Qiu-Hui, Yan Jin, Wang Xue-Dong, Wang Hui-Li
School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.
Sheng Li Xue Bao. 2023 Jun 25;75(3):439-450.
Lipid metabolism is a complex physiological process, which is closely related to nutrient regulation, hormone balance and endocrine function. It involves the interactions of multiple factors and signal transduction pathways. Lipid metabolism disorder is one of the main mechanisms to induce a variety of diseases, such as obesity, diabetes, non-alcoholic fatty liver disease, hepatitis, hepatocellular carcinoma and their complications. At present, more and more studies have found that the "dynamic modification" of N-adenylate methylation (mA) on RNA represents a new "post-transcriptional" regulation mode. mA methylation modification can occur in mRNA, tRNA, ncRNA, etc. Its abnormal modification can regulate gene expression changes and alternative splicing events. Many latest references have reported that mA RNA modification is involved in the epigenetic regulation of lipid metabolism disorder. Based on the major diseases induced by lipid metabolism disorders, we reviewed the regulatory roles of mA modification in the occurrence and development of those diseases. These overall findings inform further in-depth investigations of the underlying molecular mechanisms regarding the pathogenesis of lipid metabolism disorders from the perspective of epigenetics, and provide reference for health prevention, molecular diagnosis and treatment of related diseases.
脂质代谢是一个复杂的生理过程，与营养调节、激素平衡和内分泌功能密切相关。它涉及多种因素和信号转导途径的相互作用。脂质代谢紊乱是诱发多种疾病的主要机制之一，如肥胖症、糖尿病、非酒精性脂肪性肝病、肝炎、肝细胞癌及其并发症。目前，越来越多的研究发现，RNA上的N-腺苷酸甲基化（mA）的“动态修饰”代表了一种新的“转录后”调控模式。mA甲基化修饰可发生在mRNA、tRNA、ncRNA等上。其异常修饰可调节基因表达变化和可变剪接事件。许多最新参考文献报道，mA RNA修饰参与脂质代谢紊乱的表观遗传调控。基于脂质代谢紊乱诱发的主要疾病，我们综述了mA修饰在这些疾病发生发展中的调控作用。这些总体研究结果为从表观遗传学角度进一步深入研究脂质代谢紊乱发病机制的潜在分子机制提供了信息，并为相关疾病的健康预防、分子诊断和治疗提供了参考。
