脂质代谢与 RNA 甲基化的综合综述：生物学机制、展望与挑战。

Comprehensive review on lipid metabolism and RNA methylation: Biological mechanisms, perspectives and challenges.

机构信息

State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.

出版信息

Int J Biol Macromol. 2024 Jun;270(Pt 1):132057. doi: 10.1016/j.ijbiomac.2024.132057. Epub 2024 May 6.

DOI:10.1016/j.ijbiomac.2024.132057

PMID:38710243

Abstract

Adipose tissue plays a crucial role in maintaining energy balance, regulating hormones, and promoting metabolic health. To address disorders related to obesity and develop effective therapies, it is essential to have a deep understanding of adipose tissue biology. In recent years, RNA methylation has emerged as a significant epigenetic modification involved in various cellular functions and metabolic pathways. Particularly in the realm of adipogenesis and lipid metabolism, extensive research is ongoing to uncover the mechanisms and functional importance of RNA methylation. Increasing evidence suggests that RNA methylation plays a regulatory role in adipocyte development, metabolism, and lipid utilization across different organs. This comprehensive review aims to provide an overview of common RNA methylation modifications, their occurrences, and regulatory mechanisms, focusing specifically on their intricate connections to fat metabolism. Additionally, we discuss the research methodologies used in studying RNA methylation and highlight relevant databases that can aid researchers in this rapidly advancing field.

摘要

脂肪组织在维持能量平衡、调节激素和促进代谢健康方面发挥着关键作用。为了解决与肥胖相关的疾病并开发有效的治疗方法，深入了解脂肪组织生物学至关重要。近年来，RNA 甲基化已成为一种重要的表观遗传修饰，参与多种细胞功能和代谢途径。特别是在脂肪生成和脂质代谢领域，正在进行广泛的研究以揭示 RNA 甲基化的机制和功能重要性。越来越多的证据表明，RNA 甲基化在不同器官的脂肪细胞发育、代谢和脂质利用中发挥着调节作用。本综述旨在概述常见的 RNA 甲基化修饰及其发生和调控机制，特别关注它们与脂肪代谢的复杂联系。此外，我们还讨论了研究 RNA 甲基化的方法学，并强调了相关数据库，这些数据库可以帮助研究人员在这个快速发展的领域中取得进展。