青少年女性巨细胞病毒原发和继发感染的发生率：一项前瞻性研究的结果。
Incidence of Cytomegalovirus Primary and Secondary Infection in Adolescent Girls: Results From a Prospective Study.
机构信息
Vaccines, GSK, Rockville, Maryland, US.
VL-Medi Clinical Research Center, Helsinki, Finland.
出版信息
J Infect Dis. 2023 Nov 28;228(11):1491-1495. doi: 10.1093/infdis/jiad182.
Developing a vaccine to prevent congenital cytomegalovirus (CMV) infection and newborn disability requires an understanding of infection incidence. In a prospective cohort study of 363 adolescent girls (NCT01691820), CMV serostatus, primary infection, and secondary infection were determined in blood and urine samples collected at enrollment and every 4 months for 3 years. Baseline CMV seroprevalence was 58%. Primary infection occurred in 14.8% of seronegative girls. Among seropositive girls, 5.9% had ≥4-fold increase in anti-CMV antibody, and 23.9% shed CMV DNA in urine. Our findings provide insights on infection epidemiology and highlight the need for more standardized markers of secondary infection.
为了开发预防先天性巨细胞病毒（CMV）感染和新生儿残疾的疫苗，需要了解感染的发生率。在一项对 363 名青春期少女的前瞻性队列研究中（NCT01691820），在入组时和随后的 3 年内每 4 个月采集血液和尿液样本，以确定 CMV 血清状态、原发感染和继发感染。基线 CMV 血清流行率为 58%。14.8%的血清阴性女孩发生原发感染。在血清阳性女孩中，5.9%的人抗 CMV 抗体有≥4 倍增加，23.9%的人尿液中排出 CMV DNA。我们的研究结果提供了关于感染流行病学的见解，并强调需要更标准化的继发感染标志物。
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