Departments of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
J Infect Dis. 2010 Feb 1;201(3):386-9. doi: 10.1086/649903.
Cytomegalovirus (CMV) reinfections have been associated with damaging congenital infection and adverse outcomes in transplant recipients. To determine the frequency of and risk factors for CMV reinfections, 205 seropositive women were followed up prospectively. The appearance of new antibody specificity against 1 of 4 polymorphic epitopes was considered as evidence of CMV reinfection. Approximately one-third of the study participants (59 [29%] of 205) were noted to have CMV reinfection during follow-up. None of the exposure factors were associated with CMV reinfection. Women with antibodies against at least 1 of the 4 antigens at baseline had a 63% decreased risk of reinfection, suggesting a protective role for strain-specific immunity.
巨细胞病毒(CMV)再感染与移植受者的先天性感染和不良结局有关。为了确定 CMV 再感染的频率和危险因素,前瞻性随访了 205 例血清阳性妇女。出现针对 4 个多态性表位之一的新抗体特异性被认为是 CMV 再感染的证据。在随访期间,约三分之一的研究参与者(205 例中的 59 例[29%])被发现有 CMV 再感染。没有任何暴露因素与 CMV 再感染有关。基线时至少对 4 种抗原中的 1 种有抗体的妇女,再感染的风险降低了 63%,表明针对特定毒株的免疫具有保护作用。