Department of Education and Information Center, Lishui Municipal Central Hospital, Lishui, China.
Department of Pathology, Lishui Municipal Central Hospital, Lishui, China.
J Int Med Res. 2023 Jun;51(6):3000605231175745. doi: 10.1177/03000605231175745.
Primary malignant melanoma of the lung (PMML) is an extremely rare and refractory tumor, and its diagnosis is a significant challenge. The current study presents the case of a 62-year-old man who presented to the Department of Cardiothoracic Surgery (Lishui Municipal Central Hospital, Lishui, China) with chest tightness and fatigue for 3 months. Chest computed tomography (CT) revealed a 1.5- × 1.9-cm mass with irregular borders and heterogenous density located in the right lower lung lobe. Contrast-enhanced CT revealed slight enhancement of the mass, but there was no clear evidence of malignancy. Positron emission tomography (PET)/CT revealed a defined-margin mass, with slightly high uptake (standardized uptake value [SUV]: 3.6). The patient underwent video-assisted thoracoscopic surgery (VATS), and the final diagnosis was PMML on the basis of the results of the pathological examination. The patient received four courses of immunotherapy after the operation, and eventually declined further immunotherapy owing to the high cost. The patient was followed-up for 1 year without metastasis or recurrence.
原发性肺恶性黑色素瘤（PMML）是一种极其罕见且难治的肿瘤，其诊断极具挑战性。本研究报告了一例 62 岁男性病例，因胸闷和乏力 3 个月就诊于心胸外科（中国丽水市中心医院，丽水）。胸部 CT 显示右下肺叶有 1.5×1.9cm 大小、边界不规则、密度不均匀的肿块。增强 CT 显示肿块轻度强化，但无明确恶性证据。正电子发射断层扫描（PET）/CT 显示边界清晰的肿块，摄取稍高（标准摄取值 [SUV]：3.6）。患者接受了电视辅助胸腔镜手术（VATS），最终根据病理检查结果诊断为 PMML。术后患者接受了 4 个疗程的免疫治疗，但由于费用高昂，最终拒绝了进一步的免疫治疗。患者随访 1 年，无转移或复发。
