National University of Singapore, Singapore.
University Health Network, Toronto, ON, Canada.
J Atten Disord. 2023 Nov;27(13):1448-1459. doi: 10.1177/10870547231180111. Epub 2023 Jun 21.
Functional near-infrared spectroscopy (fNIRS) provides direct and quantitative assessment of cortical hemodynamic response. It has been used to identify neurophysiological alterations in medication-naïve adults with attention-deficit/hyperactivity disorder (ADHD). Hence, this study aimed to distinguish both medication-naïve and medicated adults with ADHD from healthy controls (HC).
75 HCs, 75 medication-naïve, and 45 medicated patients took part in this study. fNIRS signals during a verbal fluency task (VFT) were acquired using a 52-channel system and relative oxy-hemoglobin changes in the prefrontal cortex were quantified.
Prefrontal cortex hemodynamic response was lower in patients than HCs (p ≤ ≤.001). Medication-naïve and medicated patients did not differ in hemodynamic response or symptom severity (p > .05). fNIRS measurements were not associated with any clinical variables (p > .05). 75.8% patients and 76% HCs were correctly classified using hemodynamic response.
fNIRS may be a potential diagnostic tool for adult ADHD. These findings need to be replicated in larger validation studies.
功能近红外光谱（fNIRS）可提供皮质血流动力学反应的直接和定量评估。它已被用于识别未经药物治疗的注意缺陷多动障碍（ADHD）成年患者的神经生理变化。因此，本研究旨在区分未经药物治疗和经药物治疗的 ADHD 成年患者与健康对照组（HC）。
本研究共纳入 75 名 HC、75 名未经药物治疗的 ADHD 患者和 45 名经药物治疗的 ADHD 患者。使用 52 通道系统采集言语流畅性任务（VFT）期间的 fNIRS 信号，并量化前额叶皮质的相对氧合血红蛋白变化。
与 HC 相比，患者前额叶皮质的血流动力学反应较低（p≤.001）。未经药物治疗和经药物治疗的患者在血流动力学反应或症状严重程度方面无差异（p>.05）。fNIRS 测量值与任何临床变量均无相关性（p>.05）。使用血流动力学反应，75.8%的患者和 76%的 HC 被正确分类。
fNIRS 可能是成人 ADHD 的一种潜在诊断工具。这些发现需要在更大的验证研究中进行复制。
