Department of Psychiatry, Nara Medical University, Kashihara, Japan.
Faculty of Nursing, Nara Medical University, Kashihara, Japan.
Psychiatry Clin Neurosci. 2018 Jun;72(6):380-390. doi: 10.1111/pcn.12643. Epub 2018 Mar 11.
Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. In pediatric attention-deficit hyperactivity disorder (ADHD), reduced prefrontal hemodynamic responses have been observed with NIRS repeatedly. However, there are few studies of adult ADHD by multi-channel NIRS. Therefore, in this study, we used multi-channel NIRS to examine the characteristics of prefrontal hemodynamic responses during the Stroop Color-Word Task (SCWT) in adult ADHD patients and in age- and sex-matched control subjects.
Twelve treatment-naïve adults with ADHD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. We used 24-channel NIRS to measure the oxygenated hemoglobin (oxy-Hb) changes at the frontal lobes of participants during the SCWT. We compared the oxy-Hb changes between adults with ADHD and control subjects by t-tests with Bonferroni correction.
During the SCWT, the oxy-Hb changes observed in the ADHD group were significantly smaller than those in the control group in channels 11, 16, 18, 21, 22, 23, and 24, corresponding to the prefrontal cortex. At channels 16, 21, 23, and 24 of the ADHD group, there were negative correlations between the symptomatic severity and the oxy-Hb changes.
The present study suggests that adults with ADHD have reduced prefrontal hemodynamic response as measured by NIRS.
近红外光谱（NIRS）的最新发展使得人们能够在精神疾病中对大脑功能进行非侵入性的研究。在儿科注意缺陷多动障碍（ADHD）中，已经通过 NIRS 反复观察到前额叶血流动力学反应降低。然而，通过多通道 NIRS 对成人 ADHD 进行的研究很少。因此，在这项研究中，我们使用多通道 NIRS 来检查成年 ADHD 患者和年龄、性别匹配的对照组在 Stroop 颜色-单词任务（SCWT）期间前额叶血流动力学反应的特征。
在同意后，12 名未经治疗的成年 ADHD 患者和 12 名年龄、性别匹配的健康对照者参加了本研究。我们使用 24 通道 NIRS 来测量参与者在 SCWT 期间额叶的氧合血红蛋白（oxy-Hb）变化。我们通过 t 检验和 Bonferroni 校正比较了 ADHD 组和对照组之间的 oxy-Hb 变化。
在 SCWT 期间，ADHD 组在通道 11、16、18、21、22、23 和 24 观察到的 oxy-Hb 变化明显小于对照组，这些通道对应于前额叶皮质。在 ADHD 组的通道 16、21、23 和 24 中，症状严重程度与 oxy-Hb 变化之间存在负相关。
本研究表明，NIRS 测量的成人 ADHD 患者前额叶血流动力学反应降低。
