Wallach S, Verch R L
J Am Coll Nutr. 1986;5(3):291-8. doi: 10.1080/07315724.1986.10720132.
Fragmentary studies suggest that tissue chromium (Cr) levels decrease with age. Regardless of the mechanism for such a decline, decreased tissue exchange with administered radiochromium (51Cr) should result. Accordingly, body retention, urinary excretion, and serum (plasma) and tissue levels of 51Cr were determined in 2-month-old male control rats and in 9-18-month-old experimental male rats 3 days after the intravenous injection of high specific activity trivalent 51Cr. The older rats retained relatively less 51Cr than the 2-month-old rats in comparison to body weight but had similar urinary excretions of 51Cr. Serum (plasma) 51Cr levels were generally higher and tissue 51Cr levels generally lower in the older rats, with the exception of spleen 51Cr content, which increased. Skeletal 51Cr content was markedly decreased, by 30-85%. These data suggest that aging alters 51Cr distribution by decreasing cellular Cr content and transport. Other mechanisms must be operative in bone since skeletal Cr is primarily extracellular.
零散的研究表明，组织中的铬（Cr）水平会随着年龄增长而下降。无论这种下降的机制如何，给予放射性铬（51Cr）后组织交换减少都应会出现。因此，在静脉注射高比活度三价51Cr三天后，对2个月大的雄性对照大鼠和9 - 18个月大的雄性实验大鼠的身体潴留、尿排泄以及血清（血浆）和组织中的51Cr水平进行了测定。与体重相比，老年大鼠保留的51Cr比2个月大的大鼠相对较少，但51Cr的尿排泄量相似。老年大鼠的血清（血浆）51Cr水平通常较高，组织51Cr水平通常较低，但脾脏51Cr含量增加是个例外。骨骼中的51Cr含量显著下降，降幅为30% - 85%。这些数据表明，衰老通过降低细胞内铬含量和转运来改变51Cr的分布。由于骨骼中的铬主要存在于细胞外，所以在骨骼中必定存在其他作用机制。
