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六君子汤通过提高保留幽门的胰十二指肠切除术患者的胃肠和肠促胰岛素激素水平来增加食欲：一项回顾性研究。

Rikkunshito increases appetite by enhancing gastrointestinal and incretin hormone levels in patients who underwent pylorus-preserving pancreaticoduodenectomy: A retrospective study.

作者信息

Kono Hiroshi, Hosomura Naohiro, Amemiya Hidetake, Shoda Katsutoshi, Furuya Shinji, Akaike Hidenori, Kawaguchi Yoshihiko, Kawaida Hiromichi, Ichikawa Daisuke

机构信息

First Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.

出版信息

World J Gastrointest Surg. 2023 May 27;15(5):871-881. doi: 10.4240/wjgs.v15.i5.871.

DOI:10.4240/wjgs.v15.i5.871
PMID:37342846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10277958/
Abstract

BACKGROUND

Rikkunshito (TJ-43) relieves gastrointestinal disturbance by increases in the levels of acylated ghrelin.

AIM

To investigate the effects of TJ-43 in patients undergoing pancreatic surgery.

METHODS

Forty-one patients undergoing pylorus-preserving pancreaticoduodenectomy (PpPD) were divided into two groups; patients took daily doses of TJ-43 after surgery or after postoperative day (POD) 21. The plasma levels of acylated and desacylated ghrelin, cholecystokinin (CCK), peptide YY (PYY), gastric inhibitory peptide (GIP), and active glucagon-like peptide (GLP)-1 were evaluated. Oral calorie intake was assessed at POD 21 in both groups. The primary endpoint of this study was the total food intake after PpPD.

RESULTS

The levels of acylated ghrelin were significantly greater in patients treated with TJ-43 than those in patients without TJ-43 administration at POD 21, and oral intake was significantly increased in patients treated with TJ-43. The CCK and PYY levels were significantly greater in patients treated with TJ-43 than those in patients without TJ-43 treatment. Furthermore, the GIP and active GLP-1 levels increased and values at POD 21 were significantly greater in patients treated with TJ-43 than those in patients without TJ-43 administration. Insulin secretion tended to increase in patients treated with TJ-43.

CONCLUSION

TJ-43 may have advantages for oral food intake in patients in the early phase after pancreatic surgery. Further investigation is needed to clarify the effects of TJ-43 on incretin hormones.

摘要

背景

理气和中汤（TJ - 43）通过提高酰基化胃饥饿素水平来缓解胃肠道紊乱。

目的

研究TJ - 43对接受胰腺手术患者的影响。

方法

41例行保留幽门胰十二指肠切除术（PpPD）的患者被分为两组；患者在术后或术后第21天开始每日服用TJ - 43。评估血浆中酰基化和去酰基化胃饥饿素、胆囊收缩素（CCK）、肽YY（PYY）、胃抑制肽（GIP）和活性胰高血糖素样肽（GLP）-1的水平。两组均在术后第21天评估口服热量摄入。本研究的主要终点是PpPD术后的总食物摄入量。

结果

在术后第21天，服用TJ - 43的患者酰基化胃饥饿素水平显著高于未服用TJ - 43的患者，且服用TJ - 43的患者口服摄入量显著增加。服用TJ - 43的患者CCK和PYY水平显著高于未接受TJ - 43治疗的患者。此外，服用TJ - 43的患者GIP和活性GLP - 1水平升高，术后第21天的值显著高于未服用TJ - 43的患者。服用TJ - 43的患者胰岛素分泌有增加趋势。

结论

TJ - 43可能对胰腺手术后早期患者的口服食物摄入有优势。需要进一步研究以阐明TJ - 43对肠促胰岛素激素的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/fee5efcda59f/WJGS-15-871-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/bea59753cd64/WJGS-15-871-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/cb0fa3bbe470/WJGS-15-871-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/118279833f13/WJGS-15-871-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/58d94a1dbedd/WJGS-15-871-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/74ee225c2a72/WJGS-15-871-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/fee5efcda59f/WJGS-15-871-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/bea59753cd64/WJGS-15-871-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/cb0fa3bbe470/WJGS-15-871-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/118279833f13/WJGS-15-871-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/58d94a1dbedd/WJGS-15-871-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/74ee225c2a72/WJGS-15-871-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d59/10277958/fee5efcda59f/WJGS-15-871-g006.jpg

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