Otsuka H, Dolovich J, Befus A D, Telizyn S, Bienenstock J, Denburg J A
J Allergy Clin Immunol. 1986 Aug;78(2):365-71. doi: 10.1016/s0091-6749(86)80091-4.
Circulating hematopoietic progenitor cells giving rise to colonies containing basophilic cells (basophilic cell colony-forming units in culture [CFU-c]), nasal epithelial metachromatic cells (basophils and/or mast cells) (NMC), and blood basophils were enumerated before, during, and after a ragweed-pollen season in patients with ragweed hayfever and patients with perennial allergic rhinitis who were not ragweed allergic. In the patients with seasonal hay fever, the following was observed: basophilic cell CFU-c, measured as basophilic cell or histamine-containing colonies, were significantly reduced during the ragweed season compared to before (p less than 0.005) or after (p less than 0.025) the season in the ragweed-allergic group only. Conversely, peripheral blood basophils were higher during the ragweed season than before or after (p less than 0.001) in the ragweed-allergic group, whereas the number of NMC was higher during the season than before the season in this group (p less than 0.05). There were no such changes during the season in the group of patients with perennial allergic rhinitis. The observed seasonal changes in both NMC and circulating basophilic cell CFU-c are discussed in the context of lineage relationships among metachromatic cell types.
在豚草花粉季节之前、期间和之后，对豚草花粉热患者以及非豚草过敏的常年性变应性鼻炎患者的循环造血祖细胞进行计数，这些祖细胞可形成含有嗜碱性细胞的集落（培养中的嗜碱性细胞集落形成单位[CFU-c]）、鼻上皮异染性细胞（嗜碱性粒细胞和/或肥大细胞）（NMC）以及血液嗜碱性粒细胞。在季节性花粉热患者中，观察到以下情况：仅在豚草过敏组中，以嗜碱性细胞或含组胺集落测量的嗜碱性细胞CFU-c在豚草季节期间与该季节之前（p<0.005）或之后（p<0.025）相比显著减少。相反，在豚草过敏组中，外周血嗜碱性粒细胞在豚草季节期间高于该季节之前或之后（p<0.001），而该组中NMC的数量在季节期间高于季节之前（p<0.05）。常年性变应性鼻炎患者组在季节期间没有此类变化。在异染性细胞类型之间的谱系关系背景下，讨论了观察到的NMC和循环嗜碱性细胞CFU-c的季节性变化。
