Hirsch S R, Kalbfleisch J H
J Allergy Clin Immunol. 1976 Dec;58(6):676-82. doi: 10.1016/0091-6749(76)90179-2.
The relationship of hay fever symptoms and changes in the number of circulating basophils was studied in 12 subjects clinically sensitive only to ragweed and in 10 nonatopic subjects before, during, and after the ragweed season. Total white blood counts, absolute basophil counts, and symptom scores were recorded twice weekly from mid-June through October, 1974, and compared with the ragweed pollen count. The results indicated that the absolute and relative number of basophils were significantly elevated (p less than 0.001) in the hay fever group when symptoms occurred. As the symptom score of the allergic group increased during the ragweed season, the number of basophils also increased, only to decrease to control values when symptoms subsided. The basophil counts of the atopic group were significantly higher than those of the nonatopic group during the control periods. The nonatopic group also showed a significant elevation of basophils during the ragweed season, but to a much lesser extent than the atopic group. It is concluded that: (1) subjects with symptomatic hay fever have a significantly elevated absolute and relative basophil count which correlates with the exacerbation and remission of symptoms; (2) nonatopic subjects also have a small but significant elevation of basophils during the ragweed season; and (3) the elevation of basophils in the atopic group during symptoms is significantly greater than in the nonatopic group during the ragweed season.
在豚草季节之前、期间和之后，对12名仅对豚草临床敏感的受试者以及10名非特应性受试者，研究了花粉症症状与循环嗜碱性粒细胞数量变化之间的关系。1974年6月中旬至10月期间，每周记录两次白细胞总数、绝对嗜碱性粒细胞计数和症状评分，并与豚草花粉计数进行比较。结果表明，在花粉症组出现症状时，嗜碱性粒细胞的绝对数量和相对数量显著升高（p<0.001）。在豚草季节，过敏组的症状评分增加时，嗜碱性粒细胞数量也增加，症状消退时则降至对照值。在对照期，特应性组的嗜碱性粒细胞计数显著高于非特应性组。非特应性组在豚草季节也出现嗜碱性粒细胞显著升高，但程度远低于特应性组。研究得出以下结论：（1）有症状的花粉症受试者的绝对和相对嗜碱性粒细胞计数显著升高，这与症状的加重和缓解相关；（2）非特应性受试者在豚草季节也有少量但显著的嗜碱性粒细胞升高；（3）症状出现时，特应性组嗜碱性粒细胞的升高显著大于豚草季节非特应性组。
