Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA, USA; Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Neurobiol Aging. 2023 Sep;129:185-194. doi: 10.1016/j.neurobiolaging.2023.05.004. Epub 2023 May 9.
Some evidence suggests a biphasic pattern of changes in cortical thickness wherein higher, rather than lower, thickness is associated with very early Alzheimer's disease (AD) pathology. We examined whether integrating information from AD brain signatures based on mean diffusivity (MD) can aid in the interpretation of cortical thickness/volume as a risk factor for future AD-related changes. Participants were 572 men in the Vietnam Era Twin Study of Aging who were cognitively unimpaired at baseline (mean age = 56 years; range = 51-60). Individuals with both high thickness/volume signatures and high MD signatures at baseline had lower cortical thickness/volume in AD signature regions and lower episodic memory performance 12 years later compared to those with high thickness/volume and low MD signatures at baseline. Groups did not differ in level of young adult cognitive reserve. Our findings are in line with a biphasic model in which increased cortical thickness may precede future decline and establish the value of examining cortical MD alongside cortical thickness to identify subgroups with differential risk for poorer brain and cognitive outcomes.
一些证据表明，皮质厚度的变化呈双相模式，其中较高的厚度而不是较低的厚度与早期阿尔茨海默病（AD）病理有关。我们研究了基于平均弥散度（MD）的 AD 大脑特征的信息整合是否有助于解释皮质厚度/体积作为未来 AD 相关变化的风险因素。参与者是越南时代衰老双胞胎研究中的 572 名男性，他们在基线时认知正常（平均年龄为 56 岁；范围为 51-60 岁）。与基线时 MD 特征高且厚度/体积特征高的个体相比，基线时厚度/体积和 MD 特征均高的个体在 AD 特征区域的皮质厚度/体积较低，12 年后的情景记忆表现也较低。两组在年轻成人认知储备水平上没有差异。我们的发现与双相模型一致，即皮质厚度增加可能先于未来的下降，并确定了同时检查皮质 MD 和皮质厚度以识别具有不同脑和认知结果风险的亚组的价值。
