多氯联苯与女性维生素 D 的关联。
Association of polychlorinated biphenyls with vitamin D in female subjects.
机构信息
School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen, Bahrain.
School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, West Midlands, B15 2TT, UK; Queensland Alliance for Environmental Health Sciences, The University of Queensland, 39 Kessels Road, Coopers Plains, Qld, 4108, Australia.
出版信息
Environ Res. 2023 Sep 15;233:116465. doi: 10.1016/j.envres.2023.116465. Epub 2023 Jun 19.
INTRODUCTION
Polychlorinated biphenyls (PCBs) are known endocrine disrupters. A potentially causal association of PCBs with vitamin D has been reported. Higher body mass index (BMI) is associated with lower PCB levels whilst the strongest association of PCBs with BMI is in non-obese individuals. Therefore, this study examined the association of PCBs with vitamin D (25(OH)D) and the active 1,25-dihydrovitamin D (1,25(OH)D in a cohort of non-obese women.
METHODS
58 female participants (age 31.9 ± 4.6 years; BMI 25.7 ± 3.7 kg/m) had seven indicator PCBs [PCB28, PCB52, PCB101, PCB118, PCB138, PCB153 and PCB180] measured using high resolution gas chromatography, with total PCB level calculated. 25(OH)D and 1,25(OH)D levels were determined by isotope-dilution liquid chromatography tandem mass spectrometry.
RESULTS
In this cohort, vitamin D (25(OH)D) and 1,25(OH)D levels were 50.7 ± 25.3 nmol/L and 0.05 ± 0.02 ng/ml, respectively. Of those, 28 had vitamin D deficiency [25(OH)D level <20 ng/ml (<50nmol/)]. Total PCBs correlated positively with total group 25(OH)D (r = 0.22, p = 0.04) as did PCB118 (r = 0.25, p = 0.03). Total PCBs did not correlate with total group 1,25(OH)D; however, PCB180 did correlate positively with 1,25(OH)D (r = 0.34, p = 0.03) as did PCB153 (r = 0.33, p < 0.03), with PCB 28 correlating negatively (r = -0.29, p < 0.04). In the vitamin D deficient subgroup, total PCBs, PCB153 and PCB180 positively correlated with 25(OH)D (p < 0.05). Multilinear regression analysis indicated all associations could be accounted for by BMI.
CONCLUSION
Though certain PCBs associated with 25(OH)D and 1,25(OH)D, all associations could be accounted for by BMI. This study therefore indicates that the deleterious effects from PCB accumulation are not mediated by effects on 25(OH)D or 1,25(OH)D.
简介
多氯联苯（PCBs）是已知的内分泌干扰物。已经报道了 PCBs 与维生素 D 之间存在潜在的因果关系。较高的身体质量指数（BMI）与较低的 PCB 水平相关，而与 BMI 最强的 PCB 相关性存在于非肥胖个体中。因此，本研究在一组非肥胖女性中检查了 PCBs 与维生素 D（25（OH）D）和活性 1,25-二羟维生素 D（1,25（OH）D 的关联。
方法
58 名女性参与者（年龄 31.9 ± 4.6 岁；BMI 25.7 ± 3.7 kg/m）使用高分辨率气相色谱法测量了七种指示性 PCB[PCB28、PCB52、PCB101、PCB118、PCB138、PCB153 和 PCB180]，并计算了总 PCB 水平。25（OH）D 和 1,25（OH）D 水平通过同位素稀释液相色谱串联质谱法确定。
结果
在该队列中，维生素 D（25（OH）D）和 1,25（OH）D 水平分别为 50.7 ± 25.3 nmol/L 和 0.05 ± 0.02 ng/ml。其中，28 人患有维生素 D 缺乏症[25（OH）D 水平<20 ng/ml（<50nmol/）]。总 PCBs 与总 25（OH）D 呈正相关（r = 0.22，p = 0.04），PCB118 也呈正相关（r = 0.25，p = 0.03）。总 PCBs 与总 1,25（OH）D 不相关；然而，PCB180 与 1,25（OH）D 呈正相关（r = 0.34，p = 0.03），PCB153 也呈正相关（r = 0.33，p<0.03），而 PCB28 则呈负相关（r = -0.29，p<0.04）。在维生素 D 缺乏亚组中，总 PCBs、PCB153 和 PCB180 与 25（OH）D 呈正相关（p<0.05）。多元线性回归分析表明，所有关联都可以用 BMI 来解释。
结论
尽管某些 PCBs 与 25（OH）D 和 1,25（OH）D 相关，但所有关联都可以用 BMI 来解释。因此，本研究表明，PCBs 积累的有害影响不是通过对 25（OH）D 或 1,25（OH）D 的影响介导的。
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