Zhengzhou Customs Districe P.R. CHINA, Henan, PR China.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Environ Health. 2024 Oct 17;23(1):86. doi: 10.1186/s12940-024-01130-x.
Endocrine function in patients with type 2 diabetes (T2DM) typically differs from those with normal glucose tolerance (NGT). However, few epidemiologic studies have explored how these differences impact the association between exposure to polychlorinated biphenyls (PCBs) and vitamin D levels.
This study included 1,705 subjects aged 18-79 years from the Henan Rural Cohort [887 NGT and 818 T2DM]. Linear regression was applied to evaluate the associations between PCB exposure and vitamin D levels. Quantile g-computation regression (QG) and Bayesian kernel machine regression (BKMR) were applied to evaluate the impact of PCB mixtures on vitamin D levels. Interaction effects of ΣPCBs with HOMA2-%β and HOMA2-IR on vitamin D levels were assessed.
Plasma ΣPCBs was positively associated with 25(OH)D2 in the NGT group (β = 0.060, 95% CI: 0.028, 0.092). Conversely, in T2DM group, ΣPCBs was negatively associated with 25(OH)D3 and 25(OH)D (β = -0.049, 95% CI: -0.072, -0.026; β = -0.043, 95% CI: -0.063, -0.023). Similarly, both QG and BKMR analysis revealed a negative association between PCB mixture exposure and vitamin D levels in the T2DM group, contrary to the results observed in the NGT groups. Furthermore, the negative association of ΣPCBs with 25(OH)D2 and 25(OH)D disappeared or changed to a positive association with the increase of HOMA2-%β levels.
These findings suggest that decreased β cell function may exacerbate the negative effects of PCB exposure on vitamin D levels. Recognizing T2DM patients' sensitivity to PCBs is vital for protecting chronic disease health.
2 型糖尿病（T2DM）患者的内分泌功能通常与正常糖耐量（NGT）患者不同。然而，很少有流行病学研究探讨这些差异如何影响多氯联苯（PCBs）暴露与维生素 D 水平之间的关联。
本研究纳入了来自河南农村队列的 1705 名 18-79 岁的受试者[887 名 NGT 和 818 名 T2DM]。采用线性回归评估 PCB 暴露与维生素 D 水平之间的关联。采用分位数广义估计方程（QG）和贝叶斯核机器回归（BKMR）评估 PCB 混合物对维生素 D 水平的影响。评估了 ΣPCBs 与 HOMA2-%β 和 HOMA2-IR 对维生素 D 水平的交互作用。
在 NGT 组中，血浆 ΣPCBs 与 25（OH）D2 呈正相关（β=0.060，95%CI：0.028，0.092）。相反，在 T2DM 组中，ΣPCBs 与 25（OH）D3 和 25（OH）D 呈负相关（β=-0.049，95%CI：-0.072，-0.026；β=-0.043，95%CI：-0.063，-0.023）。同样，QG 和 BKMR 分析均显示，在 T2DM 组中，PCB 混合物暴露与维生素 D 水平之间存在负相关，与 NGT 组的结果相反。此外，随着 HOMA2-%β 水平的升高，ΣPCBs 与 25（OH）D2 和 25（OH）D 的负相关关系消失或转变为正相关关系。
这些发现表明，β 细胞功能下降可能会加剧 PCB 暴露对维生素 D 水平的负面影响。认识到 T2DM 患者对 PCBs 的敏感性对于保护慢性病健康至关重要。
