Lucioni Marco, Fraticelli Sara, Santacroce Giovanni, Bonometti Arturo, Aronico Nicola, Sciarra Roberta, Lenti Marco Vincenzo, Bianchi Paola Ilaria, Neri Giuseppe, Feltri Monica, Neri Benedetto, Ferrario Giuseppina, Riboni Roberta, Corazza Gino Roberto, Vanoli Alessandro, Arcaini Luca, Paulli Marco, Di Sabatino Antonio
Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
Pathology Unit, Fondazione IRCCS Policlinico S. Matteo, 27100 Pavia, Italy.
Cancers (Basel). 2023 May 13;15(10):2743. doi: 10.3390/cancers15102743.
The gastrointestinal (GI) tract is the most common extranodal site of occurrence of non-Hodgkin lymphomas. Most GI lymphomas are of B-cell lineage, while T-cell lymphomas are less frequent. The aim of our retrospective study was to depict the clinical-pathological profile of a series of patients affected by intestinal T-cell lymphomas (ITCL) and possibly define hallmarks of these neoplasms. A total of 28 patients were included: 17 enteropathy-associated T-cell lymphomas (EATL), 5 monomorphic epitheliotropic T-cell lymphomas (MEITL), 3 indolent T-cell lymphoproliferative disorders of the gastrointestinal tract (ITCLDGT), and 3 intestinal T-cell lymphomas not otherwise specified (ITCL-NOS). Celiac disease (CD) was diagnosed in around 70% of cases. Diagnosis of EATL showed a significant correlation with CD30 expression, whereas MEITL with angiotropism and CD56 positivity. ITCLDGT cases showed plasma cells infiltration. Peripheral lymphocytosis, the absence of a previous diagnosis of CD, an advanced Lugano clinical stage, and the histological subtype ITCL-NOS were significantly associated with worse survival at multivariate analysis. Our findings about the epidemiological, clinical, and histopathological features of ITCL were in line with the current knowledge. Reliable prognostic tools for these neoplasms are still lacking but according to our results lymphocytosis, diagnosis of CD, Lugano clinical stage, and histological subtype should be considered for patient stratification.
胃肠道（GI）是非霍奇金淋巴瘤最常见的结外发生部位。大多数胃肠道淋巴瘤为B细胞谱系，而T细胞淋巴瘤则较少见。我们这项回顾性研究的目的是描述一系列肠道T细胞淋巴瘤（ITCL）患者的临床病理特征，并可能确定这些肿瘤的特征。总共纳入了28例患者：17例肠病相关T细胞淋巴瘤（EATL）、5例单形性亲上皮性T细胞淋巴瘤（MEITL）、3例胃肠道惰性T细胞增殖性疾病（ITCLDGT）和3例未另行指定的肠道T细胞淋巴瘤（ITCL-NOS）。约70%的病例诊断为乳糜泻（CD）。EATL的诊断与CD30表达显著相关，而MEITL与血管侵袭和CD56阳性相关。ITCLDGT病例显示浆细胞浸润。多因素分析显示，外周血淋巴细胞增多、既往无CD诊断、卢加诺临床分期较晚以及组织学亚型ITCL-NOS与较差的生存率显著相关。我们关于ITCL的流行病学、临床和组织病理学特征的研究结果与当前认知一致。这些肿瘤仍然缺乏可靠的预后工具，但根据我们的结果，淋巴细胞增多、CD诊断、卢加诺临床分期和组织学亚型应考虑用于患者分层。
