Davis George E, Davis Matthew J, Lowell Walter E
Riverview Psychiatric Center, 250 Arsenal Street, State House Station #11, Augusta, ME, 04333-0011, USA.
Heliyon. 2023 Jun 3;9(6):e16954. doi: 10.1016/j.heliyon.2023.e16954. eCollection 2023 Jun.
Medical science needs to further elucidate the role of ultraviolet radiation (UVR), geographic latitude, and the role of vitamin D in the autoimmune disease multiple sclerosis (MS). We separated several papers into categories out of the thousands published and used their conclusions to explore the relationship between UVR and MS.
MS is increasing in incidence, particularly in women where MS is two to three times that in men and particularly severe in African Americans.
We collected UVR data at our observatory in Central Maine and calculated the average coefficient of variation (CV) for each month for 15 years (2007-2021, inclusive).
The month of conception (MOC) is more important than the month of birth (MOB) in explaining how UVR triggers the variable genetic predisposition to MS. We hypothesize that the rapidly increasing CV is important in preventing an increase in the activity of the vitamin D receptor (VDR) from August to December, which then requires a higher intensity of UVR later in life to suppress the immune system, therefore predisposing to more MS.
One observatory at about 44° latitude.
While variation in UVR is important at the MOC if UVR exceeds a threshold (e.g., if the sunspot number equals or is greater than 90, usually at a solar cycle MAX, or at elevations above approximately 3,000 feet above sea level), the MS mitigating vitamin D-VDR mechanism is overwhelmed and the genotoxic effects of higher-intensity UVR promote MS in those with a genetic predisposition.
This paper offers a new concept in MS research.
医学需要进一步阐明紫外线辐射（UVR）、地理纬度以及维生素D在自身免疫性疾病多发性硬化症（MS）中的作用。我们从数千篇已发表的论文中筛选出几类，并利用其结论来探究UVR与MS之间的关系。
MS的发病率正在上升，尤其是在女性中，女性的发病率是男性的两到三倍，在非裔美国人中尤为严重。
我们收集了缅因州中部天文台的UVR数据，并计算了15年（2007年至2021年，含）中每个月的平均变异系数（CV）。
在解释UVR如何触发MS的可变遗传易感性方面，受孕月份（MOC）比出生月份（MOB）更为重要。我们假设，快速增加的CV对于防止8月至12月维生素D受体（VDR）活性增加很重要，这就需要在以后的生活中更高强度的UVR来抑制免疫系统，从而使患MS的风险增加。
位于约北纬44°的一个天文台。
虽然在受孕月份UVR的变化很重要，但如果UVR超过阈值（例如，太阳黑子数等于或大于90，通常在太阳活动周期最大值时，或在海拔约3000英尺以上），减轻MS的维生素D-VDR机制就会不堪重负，高强度UVR的基因毒性作用会促使有遗传易感性的人患上MS。
本文在MS研究中提出了一个新概念。
