Davis George E, Lowell Walter E
Research Group, Psybernetics, Inc., 28 Eastern Ave. Augusta, ME 04330, USA.
Med Hypotheses. 2006;67(3):447-61. doi: 10.1016/j.mehy.2006.03.011. Epub 2006 May 15.
In this paper, we show that 11-year solar cycle peaks predispose humans to disease, but also endow creativity and adaptability. We give several examples of diseases that are modulated by light and present evidence for an effect of intensity and variation in sunlight, primarily ultraviolet radiation (UVR), on the human genome. The birth dates of nearly 237,000 unique clients in the Maine Medicaid database collected from 1995 to 2004, inclusive, were related to solar cycle irradiance for the past seventy-one years, encompassing seven solar cycles. The sample was divided into four general categories of disease: mental/behavioral illnesses; metabolic diseases; autoimmune diseases; neoplasms. The birth months for those clients born in any given year were arranged in the form of a winter/summer ratio in order to more clearly appreciate the seasonality inherent in each disease category. Solar cycles were separated into chaotic (approximately three times as irradiant) or non-chaotic according to the Gutenberg-Richter power law and the uncertainty inherent in predicting solar storms. The results show that radiation peaks in solar cycles and particularly in chaotic solar cycles (CSCs) are associated with a higher incidence of mental disorders, suggesting the sensitivity of ectodermal embryonic tissues to UVR. Autoimmune diseases have intermediate sensitivity, while the neoplasms in the study, primarily of endoderm, appear suppressed by peak UVR intensity. The ratio of the number of clients born in CSC cycles to non-CSC cycles was highest for the more genetic mental diseases, like schizophrenia and bipolar disorder, but as that ratio decreased, the clients with diseases like multiple sclerosis and rheumatoid arthritis showed more environmental features manifested as a greater winter/summer birth month ratio that was significantly different than that of the average client in the whole data set. The paper presents evidence that latitude, e.g., variation in light, is an added stress to the immune system (especially at 53-54 degrees N. latitude) that is involved in nearly all human disease. We hypothesize that introns, the presumptive engenderers of gene control, modulate the effects of UVR, particularly for the neoplasms studied. We conclude that intermittent and largely unpredictable peak solar cycle radiation has been the fundamental engine of evolution, forcing organisms to adapt to mutagenic UVR and producing enough damage to instigate genetic variation. Probably a chance genetic mutation over 80,000 years ago produced a human brain capable of abstract thought and consciousness. The slight genetic instability that favored an adaptable, creative brain also produced other somatic variations that present phenotypically as disease, but largely expressed after natural selection (reproduction) and associated with the inexorable entropy of aging.
在本文中，我们表明太阳活动11年周期的峰值不仅使人类易患疾病，还赋予人类创造力和适应能力。我们给出了几种受光照调节的疾病实例，并提供证据证明阳光，主要是紫外线辐射（UVR）的强度和变化对人类基因组有影响。缅因州医疗补助数据库中收集的1995年至2004年（含）近237,000名独特客户的出生日期与过去71年的太阳活动周期辐照度相关，涵盖了七个太阳活动周期。样本被分为四大类疾病：精神/行为疾病；代谢疾病；自身免疫性疾病；肿瘤。为了更清楚地了解每种疾病类别的季节性，将任何给定年份出生的那些客户的出生月份以冬夏比例的形式排列。根据古登堡 - 里希特幂律和预测太阳风暴时固有的不确定性，太阳活动周期被分为混沌（辐照度约为三倍）或非混沌。结果表明，太阳活动周期中的辐射峰值，特别是在混沌太阳活动周期（CSCs）中，与精神障碍的较高发病率相关，这表明外胚层胚胎组织对UVR敏感。自身免疫性疾病具有中等敏感性，而研究中的肿瘤主要起源于内胚层，似乎受到UVR峰值强度的抑制。对于像精神分裂症和双相情感障碍等遗传性更强的精神疾病，在混沌太阳活动周期出生的客户与非混沌太阳活动周期出生的客户数量之比最高，但随着该比例下降，患有多发性硬化症和类风湿性关节炎等疾病的客户表现出更多环境特征，表现为冬夏出生月份比例更高，且与整个数据集中普通客户的该比例有显著差异。本文提供证据表明，纬度，例如光照变化，是对免疫系统的额外压力（特别是在北纬53 - 54度），而免疫系统几乎涉及所有人类疾病。我们假设内含子作为基因控制的推定产生者，调节UVR的影响，特别是对于所研究的肿瘤。我们得出结论，间歇性且在很大程度上不可预测的太阳活动周期峰值辐射一直是进化的基本动力，迫使生物体适应致突变的UVR并产生足够的损伤以引发基因变异。大约8万年前，可能一次偶然的基因突变产生了一个能够进行抽象思维和具有意识的人类大脑。有利于适应性、创造性大脑的轻微基因不稳定性也产生了其他体细胞变异，这些变异在表型上表现为疾病，但大多在自然选择（繁殖）之后表达，并与衰老不可避免的熵相关。
