Menni Cristina, Lowell Walter E, Bentzen Joan, Bergamaschi Roberto, Martinelli Boneschi Filippo, Martinelli Vittorio, Bernardinelli Luisa, Stenager Egon, Davis George E, Foco Luisa
Department of Applied Health Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
Int J Environ Res Public Health. 2012 Mar;9(3):685-97. doi: 10.3390/ijerph9030685. Epub 2012 Feb 24.
We examined the role of ultraviolet radiation (UVR) in persons diagnosed with multiple sclerosis (MS) in four different populations, Italians, Danish, White and African Americans. We tested whether variation in UVR as determined by seasons (short term variation) and solar cycles (long term variation) is related to MS birth month and to survival as measured by lifespan. Cases were selected from three Italian MS Case Registries (2,737); from the United States National Center for Health Statistics (56,020); and from the Danish Multiple Sclerosis registry (15,900). Chi-square tests were used to study the pattern of month of birth distribution in patients with MS comparing with general population data. T-tests were employed to study solar cycles association with lifespan. A surplus of births was observed in June for White Americans. A decrease of births in October and November, though not significant after multiple testing correction, was observed in the three populations. In White American with MS overall, males and females, we found that solar cycle is associated with lifespan. We found that season and solar cycles have some role in MS susceptibility and life duration. However, this is an exploratory analysis and further work is needed to discern the association.
我们在意大利人、丹麦人、白种美国人和非裔美国人这四个不同人群中，研究了紫外线辐射（UVR）在被诊断为多发性硬化症（MS）的人群中的作用。我们测试了由季节（短期变化）和太阳周期（长期变化）所确定的UVR变化，是否与MS的出生月份以及以寿命衡量的生存情况相关。病例来自三个意大利MS病例登记处（2737例）、美国国家卫生统计中心（56020例）以及丹麦多发性硬化症登记处（15900例）。卡方检验用于研究MS患者的出生月份分布模式，并与一般人群数据进行比较。T检验用于研究太阳周期与寿命的关联。白种美国人在6月出生的人数过剩。在这三个人群中，10月和11月出生人数减少，尽管在多重检验校正后不显著。在患有MS的白种美国人总体中，无论男性还是女性，我们发现太阳周期与寿命相关。我们发现季节和太阳周期在MS易感性和寿命方面有一定作用。然而，这是一项探索性分析，需要进一步的研究来明确这种关联。
