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来自（Verhoeff）的非肽化合物及其抗肿瘤和诱导型一氧化氮合酶抑制活性。

Non-peptide compounds from (Verhoeff) and their antitumor and iNOS inhibitory activities.

作者信息

Yuan Yuan-Nan, Li Jin-Qiang, Fang Hong-Bin, Xing Shao-Jun, Yan Yong-Ming, Cheng Yong-Xian

机构信息

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.

Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, PR China.

出版信息

Beilstein J Org Chem. 2023 Jun 7;19:789-799. doi: 10.3762/bjoc.19.59. eCollection 2023.

DOI:10.3762/bjoc.19.59
PMID:37346495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10280063/
Abstract

Six new compounds, including a tetralone , two xanthones and , a flavan derivative , and two nor-diterpenoids and , accompanied by two known flavan derivatives and and a known olefine acid () were isolated from whole bodies of (Verhoeff). The structures of the new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Selected compounds were evaluated for their biological properties against a mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2 in RAW264.7 cells.

摘要

从（Verhoeff）的全体中分离出六种新化合物，包括一种四氢萘酮、两种氧杂蒽酮、一种黄烷衍生物以及两种去甲二萜类化合物，同时还分离出两种已知的黄烷衍生物以及一种已知的烯酸（）。通过一维和二维核磁共振（NMR）及其他光谱方法以及计算方法确定了新化合物的结构。对选定的化合物针对小鼠胰腺癌细胞系的生物学特性以及对RAW264.7细胞中诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的抑制作用进行了评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/5bc34893e79c/Beilstein_J_Org_Chem-19-789-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/f71fcf6efbac/Beilstein_J_Org_Chem-19-789-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/52894eb89c42/Beilstein_J_Org_Chem-19-789-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/8d157368ffe9/Beilstein_J_Org_Chem-19-789-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/5bc34893e79c/Beilstein_J_Org_Chem-19-789-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/f71fcf6efbac/Beilstein_J_Org_Chem-19-789-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/52894eb89c42/Beilstein_J_Org_Chem-19-789-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/8d157368ffe9/Beilstein_J_Org_Chem-19-789-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a8/10280063/5bc34893e79c/Beilstein_J_Org_Chem-19-789-g005.jpg

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Parvaxanthines D-F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect .来自昆虫的对映体天然杂合物——微小黄嘌呤D-F和海绵鸟苷C和D
Molecules. 2021 Jun 9;26(12):3531. doi: 10.3390/molecules26123531.
2
Encrypted antimicrobial peptides from proteins present in the plasma of the millipede Rhinocricus sp.来源于 R. rhinocricus 血浆蛋白中的加密抗菌肽
J Proteomics. 2021 Jun 30;242:104239. doi: 10.1016/j.jprot.2021.104239. Epub 2021 Apr 21.
3
Isolation, Total Synthesis, and Absolute Configuration Determination of Renoprotective Dimeric -Acetyldopamine-Adenine Hybrids from the Insect .
从昆虫中分离、全合成和确定具有肾保护作用的二聚体 -乙酰多巴胺-腺嘌呤杂合体的绝对构型。
Org Lett. 2020 Aug 7;22(15):5726-5730. doi: 10.1021/acs.orglett.0c01593. Epub 2020 Jun 11.
4
Periplanetols A-F, phenolic compounds from Periplaneta americana with potent COX-2 inhibitory activity.美洲大蠊 A-F，具有强 COX-2 抑制活性的酚类化合物。
Fitoterapia. 2020 Jun;143:104589. doi: 10.1016/j.fitote.2020.104589. Epub 2020 Apr 7.
5
Racemic xanthine and dihydroxydopamine conjugates from Cyclopelta parva and their COX-2 inhibitory activity.环斑豹鲂中的外消旋黄嘌呤和二羟多巴胺轭合物及其 COX-2 抑制活性。
Fitoterapia. 2020 Apr;142:104534. doi: 10.1016/j.fitote.2020.104534. Epub 2020 Mar 5.
6
Bioactive Polyketide Derivatives from the Mangrove-Derived Fungus HJ004.从红树林源真菌 HJ004 中分离得到的生物活性聚酮化合物衍生物。
J Nat Prod. 2019 Aug 23;82(8):2211-2219. doi: 10.1021/acs.jnatprod.9b00241. Epub 2019 Aug 2.
7
Flavan enantiomers from Daphne giraldii selectively induce apoptotic cell death in p53-null hepatocarcinoma cells in vitro.瑞香科瑞香属二氢黄酮醇对映异构体体外选择性诱导 p53 基因缺失肝癌细胞凋亡
Chem Biol Interact. 2018 Jun 1;289:1-8. doi: 10.1016/j.cbi.2018.04.014. Epub 2018 Apr 24.
8
N-containing compounds from Periplaneta americana and their activities against wound healing.美洲大蠊中的含氮化合物及其对伤口愈合的作用
J Asian Nat Prod Res. 2019 Feb;21(2):93-102. doi: 10.1080/10286020.2018.1450392. Epub 2018 Mar 29.
9
Cytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausa.与巨尾桉相关的真菌 Teratosphaeria sp. FL2137 的细胞毒性和非细胞毒性代谢产物
J Nat Prod. 2018 Mar 23;81(3):616-624. doi: 10.1021/acs.jnatprod.7b00838. Epub 2018 Jan 26.
10
Chiral Separation of Cytotoxic Flavan Derivatives from Daphne giraldii.从黄瑞香中分离细胞毒性黄酮衍生物的手性拆分
J Nat Prod. 2016 Sep 23;79(9):2236-42. doi: 10.1021/acs.jnatprod.6b00305. Epub 2016 Sep 14.