Yan Yong-Ming, Xiang Bin, Zhu Hong-Jie, Qi Jing-Jing, Hou Bo, Geng Fu-Neng, Cheng Yong-Xian
a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
b Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences , Shenzhen University Health Science Center , Shenzhen 518060 , China.
J Asian Nat Prod Res. 2019 Feb;21(2):93-102. doi: 10.1080/10286020.2018.1450392. Epub 2018 Mar 29.
Three new compounds, periplanamides A (1) and B (2), periplanpyrazine A (3), a new naturally occurring compound salicyluric acid methyl ester (6), and seventeen known compounds were isolated from the medicinal insect Periplaneta americana. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The absolute configurations of 2 were assigned by computational methods. Biological activities of these isolates except 1, 9, 11, and 13 toward nitric oxide (NO) production, cell proliferation in HDFs, cell migration and angiogenesis in HUVECs were evaluated.
从药用昆虫美洲大蠊中分离出三种新化合物，即美洲大蠊酰胺A（1）和B（2）、美洲大蠊吡嗪A（3）、一种新的天然化合物水杨酸甲酯（6）以及17种已知化合物。通过光谱方法阐明了这些新化合物的结构。化合物2的绝对构型通过计算方法确定。评估了除1、9、11和13之外的这些分离物对一氧化氮（NO）生成、人皮肤成纤维细胞（HDFs）中的细胞增殖、人脐静脉内皮细胞（HUVECs）中的细胞迁移和血管生成的生物活性。
