Li Xia, Wei Anji, Yang Yujing, Hong Jiaxu, Xu Jianjiang
Department of Ophthalmology, Shanghai Aier Eye Hospital, Shanghai, China.
Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Front Bioeng Biotechnol. 2023 Jun 6;11:1168503. doi: 10.3389/fbioe.2023.1168503. eCollection 2023.
To investigate short-term changes in corneal biomechanical properties caused by eye rubbing in myopia and emmetropia and compare the different responses between the two groups. This was a prospective observational study of 57 eyes of 57 healthy subjects aged 45 years and younger. The participants were divided into myopia and emmetropia groups. All the subjects underwent eye rubbing by the same investigator using the same technique. Biomechanical parameters were recorded using the Corvis ST device before and after 1 min of eye rubbing. One week later, all the participants underwent the test again. Statistical methods were employed to compare the differences between the data from before and after the 1 min of eye rubbing and demonstrate the different responses of the two groups. After 1 min of eye rubbing, smaller SP-A1 ( < 0.001), higher deformation and deflection amplitudes ( < 0.001, = 0.012), higher peak distances ( < 0.001), earlier A1 times ( < 0.001), faster velocities ( < 0.001), and lower maximum inverse radii ( = 0.004) were observed. According to the automatic linear modeling analysis, the refractive states (B = -5.236, = 0.010) and biomechanically corrected intraocular pressure (bIOP) (B = 0.196, = 0.016) had influenced a decrease in the stiffness parameter at the first applanation (SP-A1). The central corneal thickness (CCT) had decreased only in the myopia group ( = 0.039). The change of SP-A1 in amplitude was larger in the myopia group than in the emmetropia group ( < 0.001). All the parameters returned to the baseline level 1 week later. Eye rubbing appears to alter corneal biomechanical properties temporarily and make the cornea softer, especially for myopic young patients.
研究揉眼对近视和正视眼角膜生物力学特性的短期影响，并比较两组之间的不同反应。这是一项对57名45岁及以下健康受试者的57只眼睛进行的前瞻性观察研究。参与者被分为近视组和正视组。所有受试者均由同一名研究者采用相同技术进行揉眼。在揉眼1分钟前后，使用Corvis ST设备记录生物力学参数。一周后，所有参与者再次进行测试。采用统计方法比较揉眼1分钟前后数据的差异，并展示两组的不同反应。揉眼1分钟后，观察到较小的第一次压平刚度参数（SP-A1）（<0.001）、较高的变形和偏转幅度（<0.001，=0.012）、较高的峰值距离（<0.001）、较早的A1时间（<0.001）、较快的速度（<0.001）和较低的最大反曲率半径（=0.004）。根据自动线性建模分析，屈光状态（B=-5.236，=0.010）和生物力学校正眼压（bIOP）（B=0.196，=0.016）影响了第一次压平（SP-A1）时刚度参数的降低。仅近视组的中央角膜厚度（CCT）有所下降（=0.039）。近视组中SP-A1幅度的变化大于正视组（<0.001）。1周后所有参数均恢复到基线水平。揉眼似乎会暂时改变角膜生物力学特性，使角膜变软，尤其是对于近视年轻患者。
