Institute of Medical Psychology, Heidelberg University Hospital, Bergheimer Str. 20, 69115, Heidelberg, Germany.
Department of Gynaecological Endocrinology and Fertility Disorders, Women's Hospital of Heidelberg University, Heidelberg, Germany.
Arch Gynecol Obstet. 2023 Sep;308(3):1007-1014. doi: 10.1007/s00404-023-07097-3. Epub 2023 Jun 22.
For many couples, bearing children is a common life goal; however it cannot always be fulfilled. Undergoing infertility treatment does not always guarantee pregnancies and live births. Couples experience miscarriages and even discontinue infertility treatment. Significant medical predictors for the outcome of infertility treatment have yet to be fully identified.
To further our understanding, a cross-sectional 5-year follow-up survey was undertaken, in which 95 women and 82 men that have been treated at the Women's Hospital of Heidelberg University participated. Binary logistic regressions, parametric and non-parametric methods were used for our sample to determine the relevance of biological (infertility diagnoses, maternal and paternal age) and lifestyle factors (smoking, drinking, over- and underweight) on the outcome of infertility treatment (clinical pregnancy, live birth, miscarriage, dropout rate). In addition, chi-square tests were used to examine differences in the outcome depending on the number of risk factors being present.
In the binary logistic regression models for clinical pregnancies, live births and drop outs were statistically significant only for the maternal age, whereas the maternal and paternal BMI, smoking, infertility diagnoses and infections showed no significant predicting effect on any of the outcome variables. A correlation between the number of risk factors and the outcome of infertility treatment could not be excluded.
The results confirm that maternal age has an effect on infertility treatment, whereas the relevance of other possible medical predictors remains unclear. Further large-scale studies should be considered to increase our knowledge on their predictive power.
对于许多夫妇来说，生育子女是一个共同的生活目标；然而，并非总是能够实现这一目标。接受不孕治疗并不总能保证怀孕和活产。夫妇会经历流产，甚至停止不孕治疗。尚未充分确定不孕治疗结果的重要医学预测因素。
为了进一步了解这一点，我们进行了一项横断面 5 年随访调查，其中 95 名女性和 82 名在海德堡大学妇女医院接受治疗的男性参与了该调查。我们的样本采用二元逻辑回归、参数和非参数方法，以确定生物学因素（不孕诊断、母亲和父亲年龄）和生活方式因素（吸烟、饮酒、超重和体重不足）对不孕治疗结果（临床妊娠、活产、流产、辍学率）的相关性。此外，还使用卡方检验来检查根据存在的风险因素数量，结果的差异。
在临床妊娠、活产和辍学的二元逻辑回归模型中，仅母亲年龄具有统计学意义，而母亲和父亲的 BMI、吸烟、不孕诊断和感染对任何结果变量均无显著预测作用。不能排除风险因素数量与不孕治疗结果之间的相关性。
结果证实，母亲年龄对不孕治疗有影响，而其他可能的医学预测因素的相关性尚不清楚。应考虑进一步开展大规模研究，以增加我们对其预测能力的了解。
