Bauer Michael, Glenn Tasha, Achtyes Eric D, Alda Martin, Agaoglu Esen, Altınbaş Kürsat, Andreassen Ole A, Angelopoulos Elias, Ardau Raffaella, Aydin Memduha, Ayhan Yavuz, Baethge Christopher, Bauer Rita, Baune Bernhard T, Balaban Ceylan, Becerra-Palars Claudia, Behere Aniruddh P, Behere Prakash B, Belete Habte, Belete Tilahun, Belizario Gabriel Okawa, Bellivier Frank, Belmaker Robert H, Benedetti Francesco, Berk Michael, Bersudsky Yuly, Bicakci Şule, Birabwa-Oketcho Harriet, Bjella Thomas D, Brady Conan, Cabrera Jorge, Cappucciati Marco, Castro Angela Marianne Paredes, Chen Wei-Ling, Cheung Eric Y W, Chiesa Silvia, Crowe Marie, Cuomo Alessandro, Dallaspezia Sara, Del Zompo Maria, Desai Pratikkumar, Dodd Seetal, Etain Bruno, Fagiolini Andrea, Fellendorf Frederike T, Ferensztajn-Rochowiak Ewa, Fiedorowicz Jess G, Fountoulakis Kostas N, Frye Mark A, Geoffroy Pierre A, Gitlin Michael J, Gonzalez-Pinto Ana, Gottlieb John F, Grof Paul, Haarman Bartholomeus C M, Harima Hirohiko, Hasse-Sousa Mathias, Henry Chantal, Hoffding Lone, Houenou Josselin, Imbesi Massimiliano, Isometsä Erkki T, Ivkovic Maja, Janno Sven, Johnsen Simon, Kapczinski Flávio, Karakatsoulis Gregory N, Kardell Mathias, Kessing Lars Vedel, Kim Seong Jae, König Barbara, Kot Timur L, Koval Michael, Kunz Mauricio, Lafer Beny, Landén Mikael, Larsen Erik R, Lenger Melanie, Licht Rasmus W, Lopez-Jaramillo Carlos, MacKenzie Alan, Madsen Helle Østergaard, Madsen Simone Alberte Kongstad A, Mahadevan Jayant, Mahardika Agustine, Manchia Mirko, Marsh Wendy, Martinez-Cengotitabengoa Monica, Martini Julia, Martiny Klaus, Mashima Yuki, McLoughlin Declan M, Meesters Ybe, Melle Ingrid, Meza-Urzúa Fátima, Mikolas Pavol, Mok Yee Ming, Monteith Scott, Moorthy Muthukumaran, Morken Gunnar, Mosca Enrica, Mozzhegorov Anton A, Munoz Rodrigo, Mythri Starlin V, Nacef Fethi, Nadella Ravi K, Nakanotani Takako, Nielsen René Ernst, O'Donovan Claire, Omrani Adel, Osher Yamima, Ouali Uta, Pantovic-Stefanovic Maja, Pariwatcharakul Pornjira, Petite Joanne, Petzold Johannes, Pfennig Andrea, Ruiz Yolanda Pica, Pinna Marco, Pompili Maurizio, Porter Richard J, Quiroz Danilo, Rabelo-da-Ponte Francisco Diego, Ramesar Raj, Rasgon Natalie, Ratta-Apha Woraphat, Ratzenhofer Michaela, Redahan Maria, Reddy M S, Reif Andreas, Reininghaus Eva Z, Richards Jenny Gringer, Ritter Philipp, Rybakowski Janusz K, Sathyaputri Leela, Scippa Angela M, Simhandl Christian, Smith Daniel, Smith José, Stackhouse Paul W, Stein Dan J, Stilwell Kellen, Strejilevich Sergio, Su Kuan-Pin, Subramaniam Mythily, Sulaiman Ahmad Hatim, Suominen Kirsi, Tanra Andi J, Tatebayashi Yoshitaka, Teh Wen Lin, Tondo Leonardo, Torrent Carla, Tuinstra Daniel, Uchida Takahito, Vaaler Arne E, Vieta Eduard, Viswanath Biju, Yoldi-Negrete Maria, Yalcinkaya Oguz Kaan, Young Allan H, Zgueb Yosra, Whybrow Peter C
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
ChronoRecord Association, Fullerton, CA, USA.
Int J Bipolar Disord. 2023 Jun 22;11(1):22. doi: 10.1186/s40345-023-00303-w.
Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.
Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.
The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.
UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.
阳光中含有紫外线B（UVB）辐射，可促使皮肤产生维生素D。维生素D对发育中的大脑和成年大脑的脑功能具有广泛影响。然而，许多人生活在纬度较高（约北纬或南纬>40度）的地区，冬季无法获得足够的UVB来产生维生素D。这项探索性研究在一个大型全球样本中调查了双相I型障碍的发病年龄与足以产生维生素D的UVB阈值之间的关联。
在南北半球41个国家的75个收集地点获取了6972例双相I型障碍患者的数据。评估足以产生维生素D的UVB阈值与发病年龄之间关系的最佳模型包括低于阈值1个月或更多时间、情绪障碍家族史和出生队列。所有系数估计P≤0.001。
6972例患者在70个国家的582个地点发病，平均发病年龄为25.6岁。在发病地点中，34.0%的地点至少有1个月低于足以产生维生素D的UVB阈值。UVB低于或等于阈值1个月或更多时间的地点的发病年龄要小1.66岁。
UVB和维生素D可能对双相情感障碍的发展具有重要影响。研究的局限性包括缺乏患者维生素D水平、生活方式或补充剂使用的数据。需要更多关于UVB和维生素D对双相情感障碍影响的研究来评估这一假设。
