刺五加苷A、B、C、D、E、F和G的分离及降血糖活性：刺五加根中的聚糖

Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots.

作者信息

Hikino H, Takahashi M, Otake K, Konno C

出版信息

J Nat Prod. 1986 Mar-Apr;49(2):293-7. doi: 10.1021/np50044a015.

Abstract

Intraperitoneal injection of an aqueous extract of the crude drug "shigoka" (Siberian ginseng), Eleutherococcus senticosus roots, remarkably diminished plasma-sugar level in mice. Fractionation of the extract by monitoring the activity yielded seven glycans, eleutherans A, B, C, D, E, F, and G, which exerted marked hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.

摘要

腹腔注射粗药“shigoka”（西伯利亚人参）刺五加根的水提取物，可显著降低小鼠的血糖水平。通过监测活性对提取物进行分级分离，得到七种聚糖，即刺五加聚糖A、B、C、D、E、F和G，它们对正常小鼠和四氧嘧啶诱导的高血糖小鼠均有显著的降血糖作用。