在温和的烷化条件下激活硫代糖苷。
Activation of thioglycosides under mild alkylation conditions.
机构信息
Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St. Louis, Missouri, 63103, USA.
Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St. Louis, Missouri, 63103, USA.
出版信息
Carbohydr Res. 2023 Sep;531:108872. doi: 10.1016/j.carres.2023.108872. Epub 2023 Jun 10.
Abstract
Reported herein is the development of a novel method for the activation of thioglycosides and thioimidates using benzyl trichloroacetimidate in the presence of catalytic triflic acid. Excellent yields have been achieved with reactive substrates, whereas efficiency of reactions with unreactive glycosyl donors and/or acceptors was modest.
摘要
本文报道了一种在催化量三氟甲磺酸存在下使用苄基三氯乙酰亚胺激活硫代糖苷和硫代亚胺的新方法。该方法对活性底物具有优异的产率，而对非活性糖基供体和/或受体的反应效率则适中。
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