硫代糖苷的铜(II)溴化物活化。
Activation of Thioglycosides with Copper(II) Bromide.
机构信息
Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St. Louis, MO 63103, USA.
Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, MO 63121, USA.
出版信息
Molecules. 2022 Oct 29;27(21):7354. doi: 10.3390/molecules27217354.
Reported herein is a new protocol for glycosidation of alkyl and aryl thioglycosides in the presence of copper(II) bromide. While the activation with CuBr alone was proven suitable for reactive glycosyl donors, the activation of less reactive donors was more efficient in the presence of triflic acid as an additive. A variety of thioglycoside donors in reactions with different glycosyl acceptors were investigated to determine the initial scope of this reaction.
本文报道了一种在溴化亚铜存在下对烷基和芳基硫代糖苷进行糖苷化的新方法。虽然单独使用 CuBr 进行活化适用于反应性糖苷供体，但在添加三氟甲磺酸作为添加剂的情况下，对非反应性供体的活化更为有效。研究了不同糖苷受体与各种硫代糖苷供体的反应，以确定该反应的初始范围。
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