Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshedong Street, Zhengzhou, 450052, China.
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Curr Pharm Des. 2023;29(20):1579-1591. doi: 10.2174/1381612829666230622140926.
Lactoferrin (LF) is a protein molecule with a wide variety of physiological properties. LF has broadspectrum antibacterial, antiviral, antioxidant, and antitumor, and possesses immunomodulatory properties to regulate immunity and gastrointestinal function. The main aim of this review is to explore the recent investigations on the functional role of LF against several human disorders and diseases through monotherapy or combinatorial regimens with other biological/chemotherapeutic agents through novel nanoformulations. We significantly searched public databases such as Pubmed, National Library of Medicine, relemed, Scopus and collected published reports pertaining to these recent reports on lactoferrin as a monotherapy or combination therapy, and its nanoformulations. We have discussed vividly the role of LF as a growth factor with substantial potential that can promote cell growth and regeneration potential for repairing tissues such as bone, skin, mucosa, and tendons. In addition, we have discussed novel perspectives on the role of LF as an inductive factor for the proliferation of stem cells in tissue recovery and discussed its novel modulating effects in ameliorating cancer and microbial growth through several signaling cascades via monotherapy or combinatorial regimens. Furthermore, the regeneration potential of this protein is reviewed to explore the efficacy and prospects of new treatment methods. This review benefits various microbiologists, stem cell therapists, and oncologists to explore the efficacy of LF in several segments of medicine by examining its ability as a stem cell differentiation factor, and anticancer agent or antimicrobial agent through novel formulations in preclinical or clinical study.
乳铁蛋白（LF）是一种具有广泛生理特性的蛋白质分子。LF 具有广谱抗菌、抗病毒、抗氧化和抗肿瘤作用，并具有免疫调节特性，可调节免疫和胃肠道功能。本综述的主要目的是通过新型纳米制剂，探索 LF 在几种人类疾病和病症中的单一治疗或联合治疗方案中的功能作用的最新研究。我们通过 Pubmed、国家医学图书馆、relemed、Scopus 等公共数据库进行了深入搜索，并收集了关于乳铁蛋白作为单一治疗或联合治疗及其纳米制剂的最新报告。我们详细讨论了 LF 作为生长因子的作用，它具有促进细胞生长和再生的潜力，可以修复骨骼、皮肤、黏膜和肌腱等组织。此外，我们还讨论了 LF 作为诱导组织中干细胞增殖的因子的新观点，并讨论了其通过单一治疗或联合治疗方案通过几种信号级联在改善癌症和微生物生长方面的新调节作用。此外，还探讨了该蛋白质的再生潜力，以探索新治疗方法的疗效和前景。通过检查 LF 作为干细胞分化因子、抗癌剂或抗菌剂的能力，本综述使各种微生物学家、干细胞治疗师和肿瘤学家受益，以在医学的几个领域探索 LF 的疗效，通过新型制剂在临床前或临床试验中。
