Dávila T, San-Blas G, San-Blas F
J Med Vet Mycol. 1986 Jun;24(3):193-202.
Papulacandin B, an inhibitor of beta-glucan synthesis in some fungi, was tested on both morphological phases of Paracoccidioides brasiliensis. In vivo, the antibiotic did not affect yeast morphology or growth but it inhibited mycelial growth and yeast----mycelium transformation. Increase of alpha-glucan and decrease of beta-glucan synthesis was also observed in the fungal cell wall of the mycelial form after addition of papulacandin B. Synthesis in vitro of beta-glucan was partially substituted by the synthesis of an amylase-sensitive glucan.
巴西副球孢子菌的两个形态阶段都接受了对某些真菌中β-葡聚糖合成具有抑制作用的丘疹青霉素B的测试。在体内，这种抗生素不影响酵母形态或生长，但它抑制菌丝体生长和酵母向菌丝体的转变。在添加丘疹青霉素B后，丝状型真菌细胞壁中也观察到α-葡聚糖增加而β-葡聚糖合成减少。体外β-葡聚糖的合成部分被一种淀粉酶敏感型葡聚糖的合成所取代。
