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用于芯片上液滴生成、控制和分析的微流控深度学习技术。

Deep learning with microfluidics for on-chip droplet generation, control, and analysis.

作者信息

Sun Hao, Xie Wantao, Mo Jin, Huang Yi, Dong Hui

机构信息

School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, China.

Fujian Provincial Collaborative Innovation Center of High-End Equipment Manufacturing, Fuzhou, China.

出版信息

Front Bioeng Biotechnol. 2023 Jun 7;11:1208648. doi: 10.3389/fbioe.2023.1208648. eCollection 2023.


DOI:10.3389/fbioe.2023.1208648
PMID:37351472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10282949/
Abstract

Droplet microfluidics has gained widespread attention in recent years due to its advantages of high throughput, high integration, high sensitivity and low power consumption in droplet-based micro-reaction. Meanwhile, with the rapid development of computer technology over the past decade, deep learning architectures have been able to process vast amounts of data from various research fields. Nowadays, interdisciplinarity plays an increasingly important role in modern research, and deep learning has contributed greatly to the advancement of many professions. Consequently, intelligent microfluidics has emerged as the times require, and possesses broad prospects in the development of automated and intelligent devices for integrating the merits of microfluidic technology and artificial intelligence. In this article, we provide a general review of the evolution of intelligent microfluidics and some applications related to deep learning, mainly in droplet generation, control, and analysis. We also present the challenges and emerging opportunities in this field.

摘要

近年来,由于在基于液滴的微反应中具有高通量、高集成度、高灵敏度和低功耗等优点,液滴微流控技术受到了广泛关注。与此同时,在过去十年中随着计算机技术的快速发展,深度学习架构已能够处理来自各个研究领域的大量数据。如今,跨学科性在现代研究中发挥着越来越重要的作用,深度学习为许多专业的进步做出了巨大贡献。因此,智能微流控应运而生,并在融合微流控技术和人工智能优点的自动化和智能设备开发方面具有广阔前景。在本文中,我们对智能微流控的发展历程以及一些与深度学习相关的应用进行了综述,主要涉及液滴生成、控制和分析。我们还介绍了该领域面临的挑战和新出现的机遇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/a712eb32caab/fbioe-11-1208648-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/b9e0143bdec2/fbioe-11-1208648-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/8a4ff0100481/fbioe-11-1208648-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/9457c1707953/fbioe-11-1208648-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/29ca9cedd574/fbioe-11-1208648-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/a712eb32caab/fbioe-11-1208648-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/b9e0143bdec2/fbioe-11-1208648-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/8a4ff0100481/fbioe-11-1208648-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/9457c1707953/fbioe-11-1208648-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/29ca9cedd574/fbioe-11-1208648-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60e/10282949/a712eb32caab/fbioe-11-1208648-g005.jpg

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引用本文的文献

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Design and Implementation of a High-Throughput Digital Microfluidic System Based on Optimized YOLOv8 Object Detection.

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[2]
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本文引用的文献

[1]
Interplay between materials and microfluidics.

Nat Rev Mater. 2017-5

[2]
Paper microfluidics with deep learning for portable intelligent nucleic acid amplification tests.

Talanta. 2023-6-1

[3]
Machine-Learning-Enabled Design and Manipulation of a Microfluidic Concentration Gradient Generator.

Micromachines (Basel). 2022-10-24

[4]
Microfluidics guided by deep learning for cancer immunotherapy screening.

Proc Natl Acad Sci U S A. 2022-11-16

[5]
Deep learning detector for high precision monitoring of cell encapsulation statistics in microfluidic droplets.

Lab Chip. 2022-10-25

[6]
A survey of sound source localization with deep learning methods.

J Acoust Soc Am. 2022-7

[7]
Machine learning for microfluidic design and control.

Lab Chip. 2022-8-9

[8]
Ultrahigh efficient emulsification with drag-reducing liquid gating interfacial behavior.

Proc Natl Acad Sci U S A. 2022-7-19

[9]
Materials and methods for droplet microfluidic device fabrication.

Lab Chip. 2022-3-1

[10]
Droplet Microfluidics for High-Throughput Analysis of Antibiotic Susceptibility in Bacterial Cells and Populations.

Acc Chem Res. 2022-3-1

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