Faculty of Medicine, Institute of Physiology, Comenius University Bratislava, Bratislava, Slovakia.
Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
Eur J Oral Sci. 2023 Aug;131(4):e12940. doi: 10.1111/eos.12940. Epub 2023 Jun 23.
The consistency of the diet may affect the development and maintenance of the muscular and bony parts of the masticatory apparatus. Therefore, we investigated the effect of chronic intake of liquid nutrition (Fresubin) on the growth and maintenance of the weight and size of the skull, mandible, and teeth in Wistar rats fed with liquid nutrition during different developmental periods: (i) from weaning to adulthood, (ii) only in the juvenile period, or (iii) only in adulthood. We found that in all groups of rats fed with liquid nutrition, the skull and the mandible were significantly lighter in weight than those of control rats fed exclusively with pelleted chow from weaning to adulthood. In addition, in rats fed with liquid nutrition, the length of the mandible was significantly increased, whereas the height of the mandible and the length of the upper incisors were reduced. Our data indicate that food consistency may profoundly affect the growth pattern and the maintenance of the mass and size of skull bones and teeth during different periods of life. The extent of the effect was found to depend on the period during which liquid nutrition is provided and on the duration of its intake. In conclusion, the findings indicate that prolonged intake of liquid nutrition can significantly affect the development of the bone part of the masticatory apparatus.
饮食的一致性可能会影响咀嚼器官的肌肉和骨骼部分的发育和维持。因此，我们研究了慢性摄入液体营养（Fresubin）对 Wistar 大鼠生长和维持体重以及颅骨、下颌骨和牙齿大小的影响，这些大鼠在不同的发育阶段接受液体营养：（i）从断奶到成年，（ii）仅在青少年期，或（iii）仅在成年期。我们发现，在所有接受液体营养的大鼠组中，与从断奶到成年期仅接受颗粒状饲料的对照组大鼠相比，颅骨和下颌骨的重量明显较轻。此外，在接受液体营养的大鼠中，下颌骨的长度显著增加，而下颌骨的高度和上颌切牙的长度则减少。我们的数据表明，食物的一致性可能会深刻影响颅骨和牙齿在生命不同时期的生长模式和质量与大小的维持。影响的程度取决于提供液体营养的时期以及其摄入的持续时间。总之，这些发现表明，长期摄入液体营养会显著影响咀嚼器官的骨骼部分的发育。
