Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
PLoS One. 2023 Jun 23;18(6):e0287562. doi: 10.1371/journal.pone.0287562. eCollection 2023.
Gynaecological cancer treatment impacts women's physical and psychological health. Our objective was to examine quality of life (QoL) in women with advanced gynaecological cancer at diagnosis and one year later, and to identify sociodemographic and clinical characteristics associated with QoL.
Women with endometrial, ovarian or cervical cancer treated in Uppsala, Sweden 2012-2019 were included. FIGO stage ≥II was considered advanced gynaecological cancer, whereas women in FIGO stage I were used as a control group. QoL was assessed with SF-36. We obtained information on sociodemographic and clinical characteristics from medical records and health questionnaires. Differences in QoL domains were tested with t-tests, a mixed model ANOVA and multiple linear regression analyses.
The study population (n = 372) included 150 (40.3%) women with advanced gynaecological cancer. At diagnosis, women with advanced cancer reported lower physical (71.6 vs 81.8 (mean) p<0.05) and role functioning/physical scores (62.6 vs 77.2 (mean) p<0.05) than women in FIGO stage I. One year later, women with advanced cancer reported higher scores in the mental health domain (78.3 vs 73.2 (mean) p<0.05) than women in FIGO stage I. However, no difference was found in the QoL scores of women with advanced disease one year after diagnoses when stratified by diagnosis. Women with a history of psychiatric illness and higher BMI reported poorer physical and mental QoL at follow-up, while advanced stage, level of education and smoking were not associated with QoL.
Women with advanced gynaecological cancer have equally good QoL one year after diagnosis as women with limited disease. Women with previous psychiatric illness and high BMI, are at risk of impaired physical and mental health.
妇科癌症治疗会影响女性的身心健康。我们的目的是研究诊断时和诊断后 1 年晚期妇科癌症女性的生活质量（QoL），并确定与 QoL 相关的社会人口学和临床特征。
纳入了 2012 年至 2019 年在瑞典乌普萨拉接受治疗的子宫内膜癌、卵巢癌或宫颈癌女性。FIGO 分期≥II 期被认为是晚期妇科癌症，而 FIGO 分期 I 期的女性被用作对照组。使用 SF-36 评估 QoL。我们从病历和健康问卷中获取社会人口学和临床特征信息。使用 t 检验、混合模型方差分析和多元线性回归分析比较 QoL 领域的差异。
研究人群（n=372）包括 150 名（40.3%）晚期妇科癌症女性。诊断时，晚期癌症女性的身体功能（71.6 与 81.8（平均值），p<0.05）和角色功能/身体评分（62.6 与 77.2（平均值），p<0.05）均低于 FIGO 分期 I 期的女性。1 年后，晚期癌症女性的心理健康评分（78.3 与 73.2（平均值），p<0.05）高于 FIGO 分期 I 期的女性。然而，按诊断分层后，晚期疾病女性在诊断后 1 年的 QoL 评分无差异。有精神病史和 BMI 较高的女性在随访时的身体和心理健康状况较差，而晚期疾病、教育程度和吸烟与 QoL 无关。
诊断后 1 年，晚期妇科癌症女性的 QoL 与局限性疾病女性相当。有精神病史和 BMI 较高的女性存在身体和心理健康受损的风险。
