Ogamba Chibuzor F, Joseph Adedayo, Adefemi Ayodeji Kayode, Ezegwui Chidike Onyedikachi, Major Ajay, Jimoh Rasaq Oluwagbemiga, Orhue Michael Osahumen, Ezeanochie Michael Chudi, Ago Boniface Uji, Amah Linda Ogochukwu, Okoh Emeka Emmanuel, Idahor Courage Osamudiamen, Ejikem Mazpa, Tinworth Alexander Clive, Zisou Charilaos, Lasebikan Nwamaka N
Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
NSIA-LUTH Cancer Centre, Lagos University Teaching Hospital, Lagos, Nigeria.
Sci Rep. 2025 Jul 31;15(1):28041. doi: 10.1038/s41598-025-13763-0.
The health-related quality of life (HRQoL) and financial toxicity (FT) of women with gynecological cancers in sub-Saharan Africa have not been sufficiently explored. This study assessed predictors of HRQoL and FT, as well as the effect of FT on HRQoL, among affected women in Nigeria. This cross-sectional study investigated 574 women with gynecological cancers receiving care at various stages at five academic hospitals in southern Nigeria between June 2022 and September 2024. HRQoL and FT were evaluated using the FACT-G and FACIT-COST tools, respectively. Multivariable linear regression models estimated the associations of patient characteristics with HRQoL and FT and the effect of FT on HRQoL. Most women experienced FT. After multivariable adjustments, unemployed women, women with ovarian and uterine cancers and choriocarcinoma, higher disease stages, and worse ECOG status had worse HRQoL. Conversely, women in remission had better HRQoL. FT was worse with stages III and IV disease and in those on active treatment. However, older women, those with health insurance, higher income, ovarian cancer and choriocarcinoma had better FT. FT varied linearly with HRQoL, with better HRQoL per unit better FT. This effect was stronger in those with a first tumor, those in pre-treatment and those in remission. Our findings identify possible predictors of HRQoL and FT and suggest potential benefits of reducing FT on the HRQoL of women with gynecological cancers in Nigeria.
撒哈拉以南非洲地区妇科癌症女性的健康相关生活质量（HRQoL）和经济毒性（FT）尚未得到充分研究。本研究评估了尼日利亚受影响女性中HRQoL和FT的预测因素，以及FT对HRQoL的影响。这项横断面研究调查了2022年6月至2024年9月期间在尼日利亚南部五家学术医院接受不同阶段治疗的574名妇科癌症女性。分别使用FACT-G和FACIT-COST工具评估HRQoL和FT。多变量线性回归模型估计了患者特征与HRQoL和FT的关联以及FT对HRQoL的影响。大多数女性经历了FT。经过多变量调整后，失业女性、患有卵巢癌、子宫癌和绒毛膜癌的女性、疾病分期较高以及ECOG状态较差的女性HRQoL较差。相反，处于缓解期的女性HRQoL较好。III期和IV期疾病患者以及正在接受积极治疗的患者FT更差。然而，年龄较大的女性、有医疗保险的女性、收入较高的女性、患有卵巢癌和绒毛膜癌的女性FT较好。FT与HRQoL呈线性变化，每单位FT越好，HRQoL越好。这种效应在患有原发性肿瘤的患者、治疗前患者和缓解期患者中更强。我们的研究结果确定了HRQoL和FT的可能预测因素，并表明降低FT对尼日利亚妇科癌症女性的HRQoL可能有益。
