Department of Ophthalmology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
Department of Ophthalmology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
PLoS One. 2023 Jun 23;18(6):e0287661. doi: 10.1371/journal.pone.0287661. eCollection 2023.
Identify risk factors of progression in treated normal-tension glaucoma (NTG) in highly myopic and non-highly myopic eyes.
This retrospective, observational case series study included 42 highly myopic glaucoma (HMG, <-6D) eyes and 39 non-highly myopic glaucoma (NHG,≧-6D) eyes. Glaucoma progression was determined by serial visual field data. Univariate and multivariate logistic regression method were used to detect associations between potential risk factors and glaucoma progression.
Among 81 eyes from 81 normal-tension glaucoma patients (mean follow-up, 3.10 years), 20 of 42 eye (45.24%) in the HMG and 14 of 39 eyes (35.90%) in the NHG showed progression. The HMG group had larger optic disc tilt ratio (p = 0.007) and thinner inferior macular thickness (P = 0.03) than the NHG group. Changes in the linear regression values for MD for each group were as follows: -0.652 dB/year for the HMG and -0.717 dB/year for the NHG (P = 0.298). Basal pattern standard deviation (PSD) (OR: 1.55, p = 0.016) and post treatment IOP (OR = 1.54, p = 0.043) were risk factors for visual field progression in normal tension glaucoma patients. In subgroup analysis of HMG patients, PSD (OR: 2.77, p = 0.017) was a risk factor for visual field progression.
Reduction IOP was postulated to be contributing in the prevention of visual field progression, especially in highly myopic NTG patients with large basal pattern standard deviation.
确定高度近视和非高度近视治疗性正常眼压性青光眼（NTG）进展的危险因素。
本回顾性观察性病例系列研究纳入 42 例高度近视性青光眼（HMG，<-6D）眼和 39 例非高度近视性青光眼（NHG，≧-6D）眼。青光眼进展通过连续视野数据确定。采用单变量和多变量逻辑回归方法检测潜在危险因素与青光眼进展之间的关系。
在 81 例正常眼压性青光眼患者（平均随访 3.10 年）的 81 只眼中，42 只眼中（45.24%）的 HMG 和 39 只眼中（35.90%）的 NHG 出现进展。HMG 组视盘倾斜比（p = 0.007）和下方黄斑厚度（P = 0.03）大于 NHG 组。两组平均偏差（MD）线性回归值的变化如下：HMG 为-0.652 dB/年，NHG 为-0.717 dB/年（P = 0.298）。基础模式标准偏差（PSD）（OR：1.55，p = 0.016）和治疗后眼压（OR = 1.54，p = 0.043）是正常眼压性青光眼患者视野进展的危险因素。在 HMG 患者的亚组分析中，PSD（OR：2.77，p = 0.017）是视野进展的危险因素。
降低眼压被认为有助于预防视野进展，尤其是在基础模式标准偏差较大的高度近视 NTG 患者中。
