Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, 06273, Republic of Korea.
Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, 16995, Republic of Korea.
Clin Nutr. 2023 Aug;42(8):1292-1300. doi: 10.1016/j.clnu.2023.06.015. Epub 2023 Jun 15.
BACKGROUND & AIMS: The contribution of the balance between overall oxidative stress and antioxidant status in non-alcoholic fatty liver disease (NAFLD) is unclear. The oxidative balance score (OBS) comprises dietary and lifestyle pro- and antioxidant components that indicate the overall oxidative stress burden. We investigated the association between OBS and the incidence of NAFLD in middle-aged and older Korean adults.
Among the 10,030 participants of the Korean Genome and Epidemiology Study_Ansan and Ansung cohort, 5065 without NAFLD at baseline were selected for secondary analysis. OBS was categorized into quartiles. Multiple Cox proportional hazard regression analyses were performed to estimate the hazard ratio (HR) and 95% confidence interval (CI) for NAFLD incidence by sex-specific OBS quartile groups after adjusting for confounders.
During the follow-up period (median 13.4 years), 913 (43.2%) men and 1288 (43.9%) women were newly diagnosed with NAFLD. Compared with that of the lowest quartile (Q1) group, the adjusted HR (95% CI) for NAFLD incidence in Q2, Q3, and Q4 groups was 0.85 (0.71-1.00), 0.65 (0.54-0.78), and 0.50 (0.40-0.62) in men, and 0.85 (0.73-0.99), 0.66 (0.56-0.77), and 0.48 (0.40-0.59) in women, respectively, and for NAFLD incidence, per incremental change in OBS, was 0.90 (0.87-0.92) in men and 0.88 (0.86-0.90) in women.
A higher OBS was significantly associated with a lower risk for NAFLD incidence. Maintaining a healthy lifestyle and an antioxidant-rich diet is a potentially viable strategy for preventing NAFLD.
非酒精性脂肪性肝病（NAFLD）中整体氧化应激与抗氧化状态之间的关系尚不清楚。氧化平衡评分（OBS）包括饮食和生活方式的促氧化剂和抗氧化剂成分，可指示整体氧化应激负担。我们研究了 OBS 与中年和老年韩国成年人 NAFLD 发病之间的关系。
在韩国基因组和流行病学研究-安山和安城队列的 10030 名参与者中，选择了基线时无 NAFLD 的 5065 名参与者进行二次分析。OBS 分为四分位组。在调整混杂因素后，采用多 Cox 比例风险回归分析按性别特异性 OBS 四分位组估计 NAFLD 发病率的危险比（HR）和 95%置信区间（CI）。
在随访期间（中位数为 13.4 年），913 名（43.2%）男性和 1288 名（43.9%）女性新诊断为 NAFLD。与最低四分位（Q1）组相比，Q2、Q3 和 Q4 组的调整后 HR（95%CI）分别为男性的 0.85（0.71-1.00）、0.65（0.54-0.78）和 0.50（0.40-0.62），女性的 0.85（0.73-0.99）、0.66（0.56-0.77）和 0.48（0.40-0.59），OBS 每增加一个单位，男性的 NAFLD 发病率增加 0.90（0.87-0.92），女性的发病率增加 0.88（0.86-0.90）。
较高的 OBS 与较低的 NAFLD 发病风险显著相关。保持健康的生活方式和富含抗氧化剂的饮食可能是预防 NAFLD 的一种可行策略。
