Ketley J M, Mitchell T J, Haslam S C, Stephen J, Candy D C, Burdon D W
J Med Microbiol. 1986 Aug;22(1):33-8. doi: 10.1099/00222615-22-1-33.
The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis.
艰难梭菌产芽孢的动力学与体外艰难梭菌毒素A的释放情况并不平行。未发现毒素A与纯化的完整芽孢或芽孢衣有关。在芽孢内容物中检测到的痕量毒素A几乎肯定源自污染的营养细胞碎片。因此，毒素A不太可能是芽孢的组成成分或与孢子形成有关。
